The dark mysteries of Hinamizawa village unfold anew in the Curse Killing Arc After a short trip to the city, Keiichi Maebara returns to the small mountain hamlet where he is welcomed with a fresh batch of pranks from Satoko and the rest of his school friends. Satoko may be the youngest of the group, but she always puts on the biggest smile. Who knew her upbeat attitude masked a terrible tragedy - a year ago her older brother, her only family, vanished without a trace. Keiichi's glad to step in and act as her big brother figure, but he can't shake the nagging questions about her real brother's disappearance. Transfer student? Teenage runaway? Or could it be...Oyashiro-sama's curse?

Cerebral stroke is a common and widespread phenomenon affecting a large number of the human population worldwide. Various surgical methods have been developed for its treatment and the therapeutic results have steadily improved. This is a reassuring trend that promises further progress will be made in the future. This volume contains important contributions by leading clinicians and researchers in the field to the "International Symposium on Surgery for Cerebral Stroke" held in Sendai, Japan, May 24 - 27, 1987.

It is a great honor and pleasure for cerebral infarction have been carried me to have Springer-Verlag publish out. Dr. Yoshimoto hoped that the this volume entitled "Treatment of results of research done in our depart Cerebral Infarction." I am much in ment over the last sixteen years con debted to my colleagues for my success cerning cerebral infarction could be in publishing this book. published. Moved by his enthusiasm, I have engaged in clinical work in my colleagues took their share in writ the field of neurosurgery for these few ing each article. I suggested to them decades and I have performed more that this volume should cover primarily than 5,000 major operations of intra the results of our own research, but that cranial surgery. Throughout this time, at the same time it should also include it has been my privilege to conduct a 2- the results of related work done by neurosurgical experts throughout the hour-morning research seminar in our department every Wednesday and to world. Therefore, I hope that this book supervise a great deal of research. At will interest many investigators who these seminars my fellow research have devoted themselves to research in workers and I have exchanged many the field of neuroscience. ideas about the study of neurosurgery My colleagues acknowledge that and we have designed many animal our research has been stimulated and experiments."

Malignant glioma is generally considered one of the most therapeutically difficult cerebral tumors. This book deals with many aspects of gliomas, including factors related to incidence and epidemiology, and surveys the history of glioma therapies. Experimental studies carried out by the Sendai Group of Neurosurgeons are reported, together with the results of many clinical studies of RAFP therapy. This particular theorapy involves the administration of radiation treatment and three chemical compounds: ACNU, Futraful and PSK. A recent technique for evaluating the effectiveness of therapy based on MRI diagnostic methods is introduced. This book thus offers valuable information and guidelines for future developments in treatment.

The first mention of moyamoya disease as a distinct disease entity was in a paper I published in 1965. The abnormal net like vessels at the base of the brain seen in cerebral angio grams of this disease were described by most native speakers of Japanese as "moyamoya," a Japanese expression for some thing hazy, such as a puff of cigarette smoke drifting in the air. In fact, prior to my advocacy of this term, this type of vascular network was often referred to as "moyamoya vessels" by Japanese researchers. In 1969, Dr. A. Takaku and I submitted a paper to the Ar chives of Neurology entitled "A Disease Showing Abnormal Net-like Vessels at the base of the Brain," with a subtitle of "Moyamoya Disease." The editor, however, interchanged the main title and the subtitle and brought this term "moyamoya" to fame! Since then, researchers throughout the world have been using this poetic word! For a nicknaming godfather like me, it is a special joy to have this Japanese word enter the honored ranks ofmedica1 terminology. My first publication concerning this lesion was a report discussing six cases in 1963. Therefore it is now 20 years since I first became aware of and started to study moyamoya dis ease. At first, I merely thought that it was a strange vascular network, unique to these first few patients, and I reported these cases as being cases of acquired collateral vessels.