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An international team of investigators presents thought-provoking
reviews of bioreactors for stem cell expansion and differentiation
and provides cutting-edge information on different bioreactor
systems. The authors offer novel insights into bioreactor-based
culture systems specific for tissue engineering, including
sophisticated and cost-effective manufacturing strategies geared to
overcome technological shortcomings that currently preclude
advances towards product commercialization. This book in the fields
of stem cell expansion, bioreactors, bioprocessing, and bio and
tissue engineering, gives the reader a full understanding of the
state-of-art and the future of these fields. Key selling features:
Describes various bioreactors or stem cell culturing systems
Reviews methods for stem cell expansion and differentiation for
neural, cardiac, hemopoietic, mesenchymal, hepatic and other
tissues cell types Distinguishes different types of bioreactors
intended for different operational scales of tissue engineering and
cellular therapies Includes contributions from an international
team of leaders in stem cell research
Contents: 1. New Methodologies for Multiphase Bioreactors 1: Hydrodynamic and Mass Transfer Characteristics of Multistage Slurry Reactors 2. New Methodologies for Multiphase Bioreactors 2: Image Analysis and Multiphase Bioreactors 3. New Methodologies for Multiphase Bioreactors 3: data Acquisition, Modelling and Control 4. Design and Modelling of Immobilised Biocatalytic Reactors 5. Advances in the Selection and Design of Two-Liquid Phase Biocatalytic Reactors 6. Enzymatic Membrane Reactors 7. Reversed Micellar Bioreaction Systems: Principles and Operation 8. Solid-to-Solid Bioconversions: Batch or Continuous? 9. Solid/Gas Systems, Theory and Applications 10. Biofilm Reactors 11. Pulsing Bioreactors 12. Design of Liquid-Liquid-Solid Fluidises-Bed Bioreactors 13. Flocculation Bioreactors 14. Bioreactor Design For Plant Cell Suspension Cultures 15. Lethal Effects of Bubbles in Animal-Cell Culture 16. A Low-Cost Technology for Entomopathogenic Nematode Large-Scale Production 17. Marine Sponges as Biocatalysts
An international team of investigators presents thought-provoking
reviews of bioreactors for stem cell expansion and differentiation
and provides cutting-edge information on different bioreactor
systems. The authors offer novel insights into bioreactor-based
culture systems specific for tissue engineering, including
sophisticated and cost-effective manufacturing strategies geared to
overcome technological shortcomings that currently preclude
advances towards product commercialization. This book in the fields
of stem cell expansion, bioreactors, bioprocessing, and bio and
tissue engineering, gives the reader a full understanding of the
state-of-art and the future of these fields. Key selling features:
Describes various bioreactors or stem cell culturing systems
Reviews methods for stem cell expansion and differentiation for
neural, cardiac, hemopoietic, mesenchymal, hepatic and other
tissues cell types Distinguishes different types of bioreactors
intended for different operational scales of tissue engineering and
cellular therapies Includes contributions from an international
team of leaders in stem cell research
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Stem Cell Manufacturing (Hardcover)
Joaquim M.S. Cabral, Claudia Lobato De Silva, Lucas G. Chase, Maria Margarida Diogo
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R4,567
Discovery Miles 45 670
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Ships in 12 - 17 working days
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Stem Cell Manufacturing discusses the required technologies that
enable the transfer of the current laboratory-based practice of
stem cell tissue culture to the clinic environment as therapeutics,
while concurrently achieving control, reproducibility, automation,
validation, and safety of the process and the product. The advent
of stem cell research unveiled the therapeutic potential of stem
cells and their derivatives and increased the awareness of the
public and scientific community for the topic. The successful
manufacturing of stem cells and their derivatives is expected to
have a positive impact in the society since it will contribute to
widen the offer of therapeutic solutions to the patients. Fully
defined cellular products can be used to restore the structure and
function of damaged tissues and organs and to develop stem
cell-based cellular therapies for the treatment of cancer and
hematological disorders, autoimmune and other inflammatory diseases
and genetic disorders.
Engineering Strategies for Regenerative Medicine considers how
engineering strategies can be applied to accelerate advances in
regenerative medicine. The book provides relevant and up-to-date
content on key topics, including the interdisciplinary integration
of different aspects of stem cell biology and technology, diverse
technologies, and their applications. By providing massive amounts
of data on each individual, recent scientific advances are rapidly
accelerating medicine. Cellular, molecular and genetic parameters
from biological samples combined with clinical information can now
provide valuable data to scientists, clinicians and ultimately
patients, leading to the development of precision medicine. Equally
noteworthy are the contributions of stem cell biology,
bioengineering and tissue engineering that unravel the mechanisms
of disease, regeneration and development.
1. Chromatographic Processes.- Modelling Equilibrium and Kinetics
in Chromatographic Processes.- Theory of Linear and Nonlinear
Chromatography.- Hydrodynamics of Chromatographic Columns.- Cyclic
Fixed Bed Sorption Processes for Bioseparations - Design Aspects.-
Separations by Continuous Annular Chromatography.- Gradient Elution
Chromatography.- Rate Processes in Supercritical Fluid Desorption
and Extraction.- 2. Membrane Processes.- Fundamentals of Membrane
Separation Processes.- Pressure-Driven Membrane Processes.-
Ellectrically-Driven Membrane Processes.- Novel Membranes -
Formation and Process Applications.- Cell Harvesting Using
Cross-Flow Microfiltration.- Recovery of Intracellular Products.-
Pervaporation in Biotechnology.- 3. Affinity Processes.- Affinity
Chromatography: Principles and Applications.- Theory of Affinity
Chromatography.- Affinity Partitioning.- Prediction of Partition
Coefficients for Peptides in Aqueous Two-Phase Systems.- Membrane
Affinity Filtration.- 4. Design of Separation Media.- Affinity
Chromatography: Design of Biospecific Chromatographic Materials.-
Membranes for Bioprocessing: Design Considerations.- 5. Scale-Up,
Optimization and Process Integration.- Operating Modes, Scale-up
and Optimization of Chromatographic Processes.- Scale-up and
Optimization of Membrane Processes.- Simultaneous Reaction and
Chromatography.- Membrane bioreactors.- Recombinant Human
Tissue-Plasminogen Activator: Biochemistry, Pharmacology, and
Process Development.- List of Contributors and Participants.
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