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The 6th volume of the book series Acute Leukemias presents both
therapeutic and prognostic updates of the most recent results of
major multicenter clinical trials. Additional chapters report on
new trends in leucemia cell biology, the monitoring of minimal
residual disease and secondary leucemias as well as new
antileucemic drugs, antimicrobial strategies and the use of
cytocines. Acute Leukemias VI provides a new update on the rapid
progress being made internationally concerning leucemic diseases.
Before use, standard ERP systems such as SAP R/3 need to be
customized to meet the concrete requirements of the individual
enterprise. This book provides an overview of the process models,
methods, and tools offered by SAP and its partners to support this
complex and time-consuming process. It begins by characterizing the
foundations of the latest ERP systems from both a conceptual and
technical viewpoint, whereby the most important components and
functions of SAP R/3 are described. The main part of the book then
goes on to present the current methods and tools for the R/3
implementation based on newer process models (roadmaps).
Before use, standard ERP systems such as SAP R/3 need to be customized to meet the concrete requirements of the individual enterprise. This book provides an overview of the process models, methods, and tools offered by SAP and its partners to support this complex and time-consuming process. It begins by characterizing the foundations of the latest ERP systems from both a conceptual and technical viewpoint, whereby the most important components and functions of SAP R/3 are described. The main part of the book then goes on to present the current methods and tools for the R/3 implementation based on newer process models (roadmaps).
The results of treatment for childhood acute myelogenous leukemia
(AML) have improved considerably during the last ten years. This
progress was demonstrated by the two consecutive multicenter
studies, AML-BFM-78 and -83, in which almost identical extended
multi drug regimes of che motherapy were administered for eight
weeks and followed up by two years maintenance. The main difference
in the second study was the addition of an eight-day intensive in
duction course. Due to this new element, the relapse rate was
reduced significantly. Another result of the BFM-83 study was the
definition of two risk groups on the basis of standardized
treatment, which has lead to a risk-adapted treatment strategy in
the third ongoing trial, AML-BFM- 87. This improvement was only
possible thanks to the coop eration of pediatricians, physicians,
radiotherapists, statisti cians, and especially the staff at the
hospitals and reference laboratories. Thus, we would like to thank
everyone who has been involved in these studies and hope that they
will be further encouraged to improve treatment strategies for AML
in children. The coordination, enforcement, and analyses of the
stud ies would not have been possible without the financial sup
port of the Federal Ministry for Research and Technology of the
FRG. We are grateful for the generous contributions supporting this
book from Lederle and Farmitalia. Munster, April 1990 Ursula
Creutzig Jorg Ritter Gunther Schellong Contents 1 Introduction . .
. . .. . . . . . . . . . . . . . . .. . . . 1 ."
Acute leukemia a quite homogenous disease failed to break through
the sound barriere of when untreated reveals a substantial hetero
unsatisfactory cure rates even in special sub geneity in its
response to therapy. While cure groups. While new protocols
including more is achieved in a certain proportion of pa effective
supportive care show some increase tients other cases prove to be
highly resis in the initial response rates and certain im tant. The
curability is superior in acute provements in the long-term
results, no ben lymphoblastic (ALL) than in acute myeloid eficial
effect on the relapse rate during the (AML) leukemia and - within
both type- first 1 Y2 years emerged from any of these higher in
children as compared to adults. regimens. Thus, high chances for
cure are The two age groups and cell types can be presently
restricted to children with ALL further subdivided into prognostic
groups and to lesser proportions children with by special
diagnostic features. Thus, in AML and adults with ALL and AML.
You see things, and sa)' why? But I dream 1hings that never were,
and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time,
June 1st, 1909, Alexander Maximov communicated in a lecture, given
in the Charite in Berlin, the fundamental knowledge, that there
exists a lymphoid hemopoetic stem cell. Alexander Friedenstein
explained that during the following years, Maximov also showed that
the idea of interaction between hemopoetic cells and their stroma
to be one of the most significant experiences. Monoclonal
antibodies, recombinant DNA technics and the improvement of tissue
culture models are the major developments to improve our
possibilities to clarify growth and differentiation functions of
hemopoetic cells. During the last two decades it was shown that
soluble products, released from T cells, were not only involved in
inducing B cells to produce specific immunoglobulin secretion after
antigen stimulation. Furthermore, lymphokines together with other
cytokines regulate the growth and differentiation of hemopoetic
cells. As I have learned from Dick Gershon, our knowledge of the
cellular basis for immunoregulation has come a long way since 450
B.C. Thucydides comments on the possible role of immune response in
controlling the Black Death. Dick Gershon speculated that no
scientific interest for these interesting observations was put
forth at that time. Perhaps the problems, the Athenians were having
with the Spartans, converted money from basis research into the
military budget.
Before use, standard ERP systems such as SAP R/3 need to be
customized to meet the concrete requirements of the individual
enterprise. This book provides an overview of the process models,
methods, and tools offered by SAP and its partners to support this
complex and time-consuming process. It begins by characterizing the
foundations of the latest ERP systems from both a conceptual and
technical viewpoint, whereby the most important components and
functions of SAP R/3 are described. The main part of the book then
goes on to present the current methods and tools for the R/3
implementation based on newer process models (roadmaps).
Before use, standard ERP systems such as SAP R/3 need to be
customized to meet the concrete requirements of the individual
enterprise. This book provides an overview of the process models,
methods, and tools offered by SAP and its partners to support this
complex and time-consuming process. It begins by characterizing the
foundations of the latest ERP systems from both a conceptual and
technical viewpoint, whereby the most important components and
functions of SAP R/3 are described. The main part of the book then
goes on to present the current methods and tools for the R/3
implementation based on newer process models (roadmaps).
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