The 6th volume of the book series Acute Leukemias presents both therapeutic and prognostic updates of the most recent results of major multicenter clinical trials. Additional chapters report on new trends in leucemia cell biology, the monitoring of minimal residual disease and secondary leucemias as well as new antileucemic drugs, antimicrobial strategies and the use of cytocines. Acute Leukemias VI provides a new update on the rapid progress being made internationally concerning leucemic diseases.

Before use, standard ERP systems such as SAP R/3 need to be customized to meet the concrete requirements of the individual enterprise. This book provides an overview of the process models, methods, and tools offered by SAP and its partners to support this complex and time-consuming process. It begins by characterizing the foundations of the latest ERP systems from both a conceptual and technical viewpoint, whereby the most important components and functions of SAP R/3 are described. The main part of the book then goes on to present the current methods and tools for the R/3 implementation based on newer process models (roadmaps).

Before use, standard ERP systems such as SAP R/3 need to be customized to meet the concrete requirements of the individual enterprise. This book provides an overview of the process models, methods, and tools offered by SAP and its partners to support this complex and time-consuming process. It begins by characterizing the foundations of the latest ERP systems from both a conceptual and technical viewpoint, whereby the most important components and functions of SAP R/3 are described. The main part of the book then goes on to present the current methods and tools for the R/3 implementation based on newer process models (roadmaps).

The results of treatment for childhood acute myelogenous leukemia (AML) have improved considerably during the last ten years. This progress was demonstrated by the two consecutive multicenter studies, AML-BFM-78 and -83, in which almost identical extended multi drug regimes of che motherapy were administered for eight weeks and followed up by two years maintenance. The main difference in the second study was the addition of an eight-day intensive in duction course. Due to this new element, the relapse rate was reduced significantly. Another result of the BFM-83 study was the definition of two risk groups on the basis of standardized treatment, which has lead to a risk-adapted treatment strategy in the third ongoing trial, AML-BFM- 87. This improvement was only possible thanks to the coop eration of pediatricians, physicians, radiotherapists, statisti cians, and especially the staff at the hospitals and reference laboratories. Thus, we would like to thank everyone who has been involved in these studies and hope that they will be further encouraged to improve treatment strategies for AML in children. The coordination, enforcement, and analyses of the stud ies would not have been possible without the financial sup port of the Federal Ministry for Research and Technology of the FRG. We are grateful for the generous contributions supporting this book from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 Introduction . . . . .. . . . . . . . . . . . . . . .. . . . 1 ."

Acute leukemia a quite homogenous disease failed to break through the sound barriere of when untreated reveals a substantial hetero unsatisfactory cure rates even in special sub geneity in its response to therapy. While cure groups. While new protocols including more is achieved in a certain proportion of pa effective supportive care show some increase tients other cases prove to be highly resis in the initial response rates and certain im tant. The curability is superior in acute provements in the long-term results, no ben lymphoblastic (ALL) than in acute myeloid eficial effect on the relapse rate during the (AML) leukemia and - within both type- first 1 Y2 years emerged from any of these higher in children as compared to adults. regimens. Thus, high chances for cure are The two age groups and cell types can be presently restricted to children with ALL further subdivided into prognostic groups and to lesser proportions children with by special diagnostic features. Thus, in AML and adults with ALL and AML.

You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget.

Before use, standard ERP systems such as SAP R/3 need to be customized to meet the concrete requirements of the individual enterprise. This book provides an overview of the process models, methods, and tools offered by SAP and its partners to support this complex and time-consuming process. It begins by characterizing the foundations of the latest ERP systems from both a conceptual and technical viewpoint, whereby the most important components and functions of SAP R/3 are described. The main part of the book then goes on to present the current methods and tools for the R/3 implementation based on newer process models (roadmaps).

Before use, standard ERP systems such as SAP R/3 need to be customized to meet the concrete requirements of the individual enterprise. This book provides an overview of the process models, methods, and tools offered by SAP and its partners to support this complex and time-consuming process. It begins by characterizing the foundations of the latest ERP systems from both a conceptual and technical viewpoint, whereby the most important components and functions of SAP R/3 are described. The main part of the book then goes on to present the current methods and tools for the R/3 implementation based on newer process models (roadmaps).