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Proceedings of the European Cooperation in the Field of Scientific
and Technical Research (COST 825) Symposium on Mammary Gland
Biology, held September 16-18, 1999, in Tours, France. It is
difficult to overstate the evolutionary and functional significance
of mammary tissue in biology. Substantial progress has been made by
researchers in various disciplines, particularly over the last
fifteen years, towards realizing the potential of this tissue to
yield powerful experimental models for morphogenesis and tissue
development; for cellular differentiation; for the biosynthesis and
secretion of proteins, lipids, small molecules and inorganic salts;
and for the coordination and regulation of these processes. More
recently, the possibility of exploiting the secretory epithelial
cells of mammary tissue as `cell factories' has become a reality
and the recombinant production by lactating animals of an
increasing number of proteins, valuable both in the pharmaceutical
and `nutraceutical' fields, is in progress or under development.
Also in this sphere of agricultural production, genetic as well as
nutritional technologies are under investigation and exploitation
to optimize milk composition for various end-uses - for instance in
food process and manufacture. The possibilities of deriving health
benefit from the bioactive properties of some of the minor
constituents of milk are emerging to counter the highly-publicized
negative health impact of excessive consumption of saturated animal
fats. In human nutrition and medicine, the mammary gland is both a
source of nutrition to the neonate and a potential health threat to
the adult female - breast cancer remains the major single cause of
female mortality in most developed countries. This volume provides
a unique glimpse into our understanding, at the cutting edge of a
variety of disciplines, of this versatile and extraordinary tissue,
at the birth of the twenty-first century.
Proceedings of the European Cooperation in the Field of Scientific
and Technical Research (COST 825) Symposium on Mammary Gland
Biology, held September 16-18, 1999, in Tours, France. It is
difficult to overstate the evolutionary and functional significance
of mammary tissue in biology. Substantial progress has been made by
researchers in various disciplines, particularly over the last
fifteen years, towards realizing the potential of this tissue to
yield powerful experimental models for morphogenesis and tissue
development; for cellular differentiation; for the biosynthesis and
secretion of proteins, lipids, small molecules and inorganic salts;
and for the coordination and regulation of these processes. More
recently, the possibility of exploiting the secretory epithelial
cells of mammary tissue as cell factories' has become a reality and
the recombinant production by lactating animals of an increasing
number of proteins, valuable both in the pharmaceutical and
nutraceutical' fields, is in progress or under development. Also in
this sphere of agricultural production, genetic as well as
nutritional technologies are under investigation and exploitation
to optimize milk composition for various end-uses - for instance in
food process and manufacture. The possibilities of deriving health
benefit from the bioactive properties of some of the minor
constituents of milk are emerging to counter the highly-publicized
negative health impact of excessive consumption of saturated animal
fats. In human nutrition and medicine, the mammary gland is both a
source of nutrition to the neonate and a potential health threat to
the adult female - breast cancer remains the major single cause of
female mortality in most developed countries. This volume provides
a unique glimpse into our understanding, at the cutting edge of a
variety of disciplines, of this versatile and extraordinary tissue,
at the birth of the twenty-first century.
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