Encouraged by the medicinal success of quinine, early 19th century scientists hoped strychnine, another plant alkaloid with remarkable properties, might also become a new weapon against disease. Physicians tried for over a century, despite growing evidence to the contrary, to treat everything from paralysis to constipation with it. But strychnine proved only to be disappointingly deadly-relegating its fate almost entirely to animal control, the dangerous adulteration of foods, and criminal exploits. The NOTORIOUS and TRUE story of how a POISONOUS alkaloid... Bitter Nemesis: The Intimate History of Strychnine presents a scholarly and compelling history of this fascinating chemical substance from its discovery to present times. A renowned editor for the Dictionary of Natural Products, Dr. John Buckingham fuses his eclectic interests into an extraordinary mix of original research spanning the realms of history, medicine, literature, chemistry, and forensics. ...Changed the course of HISTORY! Uncovering details and logistics from the earliest experiments performed in an era when proper scientific trials for testing new drugs were still in their infancy, the author explores strychnine's trial-and-error contributions to scientific, medical, and forensic developments. He also investigates historical milestones and the perception of strychnine in popular culture-including criminal notoriety, accidental misuse, and new claims of strychnine's benefits that extend through to the present day. Juxtaposing the real trials, mistrials, and persistent curiosity associated with one of history's most notorious pharmaceutical failures, Bitter Nemesis offers rare insight into the anarchic, yet inspired landscape, practices, and legacy of 19th century science.

This second supplement to the edition of the Dictionary of Organic Compounds, published in 1995, extends the literature coverage of the dictionary to mid-1996. It includes over 2,500 entries, some of which are major updates to entries which appeared in volumes 1-9, while the majority are new entries based on the editorial team's ongoing review of the current literature. Some of these cover recently synthesized molecules of research interest, while others refer to known compounds which have come into prominence, for example as synthetic reagents in new methodologies. The Supplement contains its own Name, Molecular Formula and CAS Registry Number Indexes.

Written by the team that brought you the prestigious Dictionary of Natural Products (DNP), the Natural Products Desk Reference provides a concise overview of the key structural types of natural products and their interrelationship. A structurally diverse group, ranging from simple aliphatic carbon chains to high molecular weight proteins, natural products can usually be classified into one or more groups. The text describes these major types, including flavonoids, carbohydrates, terpenoids, polyketides, and lipids, and it illustrates them with accurate chemical structures, demonstrating the biosynthetic relationships between groups. Provides details of specialist natural products journals and journals in biochemistry, biology, medicinal chemistry, organic chemistry, pharmacy, pharmacology, and toxicology that may contain important information on natural products Includes types of names that can be used for natural products, comprising functional parent names, trivial names, systematic names, semisystematic names, and semitrivial names Covers stereochemistry topics specific to natural products Presents an overview of the natural world and its classification, focusing on organisms that are the richest sources of natural products Details known types of natural product skeletons with their numbering, or where there are skeletal variations within the group, an illustration is given of a representative example compound Discusses carbohydrate nomenclature impacts on stereochemistry, and on the nomenclature of compounds other than mainstream carbohydrates Reviews general precautions for handling chemicals in a laboratory environment, highlighting hazards resulting from the acute toxicological and pharmacological properties of some classes of natural products and hazards associated with the use o

Encouraged by the medicinal success of quinine, early 19th century scientists hoped strychnine, another plant alkaloid with remarkable properties, might also become a new weapon against disease. Physicians tried for over a century, despite growing evidence to the contrary, to treat everything from paralysis to constipation with it. But strychnine proved only to be disappointingly deadly-relegating its fate almost entirely to animal control, the dangerous adulteration of foods, and criminal exploits. The NOTORIOUS and TRUE story of how a POISONOUS alkaloid... Bitter Nemesis: The Intimate History of Strychnine presents a scholarly and compelling history of this fascinating chemical substance from its discovery to present times. A renowned editor for the Dictionary of Natural Products, Dr. John Buckingham fuses his eclectic interests into an extraordinary mix of original research spanning the realms of history, medicine, literature, chemistry, and forensics. ...Changed the course of HISTORY! Uncovering details and logistics from the earliest experiments performed in an era when proper scientific trials for testing new drugs were still in their infancy, the author explores strychnine's trial-and-error contributions to scientific, medical, and forensic developments. He also investigates historical milestones and the perception of strychnine in popular culture-including criminal notoriety, accidental misuse, and new claims of strychnine's benefits that extend through to the present day. Juxtaposing the real trials, mistrials, and persistent curiosity associated with one of history's most notorious pharmaceutical failures, Bitter Nemesis offers rare insight into the anarchic, yet inspiredlandscape, practices, and legacy of 19th century science.

Written by the team that brought you the prestigious Dictionary of Natural Products (DNP), the Natural Products Desk Reference provides a concise overview of the key structural types of natural products and their interrelationship. A structurally diverse group, ranging from simple aliphatic carbon chains to high molecular weight proteins, natural products can usually be classified into one or more groups. The text describes these major types, including flavonoids, carbohydrates, terpenoids, polyketides, and lipids, and it illustrates them with accurate chemical structures, demonstrating the biosynthetic relationships between groups. Provides details of specialist natural products journals and journals in biochemistry, biology, medicinal chemistry, organic chemistry, pharmacy, pharmacology, and toxicology that may contain important information on natural products Includes types of names that can be used for natural products, comprising functional parent names, trivial names, systematic names, semisystematic names, and semitrivial names Covers stereochemistry topics specific to natural products Presents an overview of the natural world and its classification, focusing on organisms that are the richest sources of natural products Details known types of natural product skeletons with their numbering, or where there are skeletal variations within the group, an illustration is given of a representative example compound Discusses carbohydrate nomenclature impacts on stereochemistry, and on the nomenclature of compounds other than mainstream carbohydrates Reviews general precautions for handling chemicals in a laboratory environment, highlighting hazards resulting from the acute toxicological and pharmacological properties of some classes of natural products and hazards associated with the use of organic solvents In addition to being a companion resource to the DNP, the Natural Products Desk Reference provides you with a mass of other useful information which can sometimes be hard to track down. In compiling it, the authors have drawn on over 20 years of day-to-day experience in the description and classification of all types of natural product.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone

This scarce antiquarian book is a selection from Kessinger PublishingA AcentsAcentsa A-Acentsa Acentss Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of intere

Widely distributed throughout plant families, flavonoids give many flowers and fruits their vibrant colors. They also play a role in protecting the plants from microbe and insect attacks. More importantly, the consumption of foods containing flavonoids has been linked to numerous health benefits. Recent research indicates that flavonoids can be nutritionally helpful by triggering enzymes that reduce the risk of certain cancers, heart disease, and age-related degenerative diseases. Foods that contain high amounts of flavonoids include blueberries, red beans, cranberries, and blackberries. Many other foods, including red and yellow fruits and vegetables and some nuts, as well as red wine and certain teas are also rich in flavonoids. Due the potential health benefits, research into flavonoids and their potential beneficial effects on human health continues unabated. Dictionary of Flavonoids with downloadable resources lists all known flavonoids (approximately 13,000) in a single volume. It details chemical structures, physical properties, and biological source, and also includes a concise bibliography. Derived from the well-respected Dictionary of Natural Products, it is presented in a compact dictionary format, and is an invaluable reference source for all those working in this area. The book is accompanied by downloadable resources that are fully searchable by chemical structure as well as by physical properties and chemical names. Organized in alphabetical order, each page is packed with authoritative information that readers can easily access. The book and downloadable resource combination gives researchers powerful tools for unlocking and utilizing the secrets held within the colors of the plant kingdom.

Containing fully authenticated data on virtually all known natural products, the Dictionary of Natural Products, main work, published in 1993 was the end result of over 12 years compilation and editing by a large team of contributors and the editorial staff of the Chapman & Hall Scientific Data Division. The resulting Dictionary contains 100,000 natural products and their derivatives organised into approximately 35,000 entries.