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Free Radicals/Ischemia Reperfusion Injury: Basal Relief of EDRF
under Conditions of Oxidant Stress; N. Marczin, et al. Invasion and
Neoplasia: Interaction of Malaria-Infected Cells with the Vascular
Wall; G. Senaldi, et al. EndothelialTumor Cell Interactions In
vitro and In vivo; R. Giavazzi, et al. Altered Vascular Reactivity:
Altered Vascular Reactivity in Coronary Artery Disease; J.
Zanzinger, E. Bassenge. Isoforms of Nitric Oxide Synthase and the
Nitric Oxide-Cycle GMP Signal Transduction System; F. Murad, et al.
Inflamation/Atherosclerosis: Proinflammatory Role of Leukocyte
Adhesion Molecules; J.M. Harlan, et al. Circulating Endothelial
Adhesion Molecules; J.L. Gordon, et al. Organ
Transplantation/Rejection: Experimental Cell Transplantation and
Gene Therapy Techniques in the Treatment of Liver Disease; A.A.
Demetriou, et al. 6 additional articles. Index.
Proceedings of a NATO ARW held in Crete, Greece, June 22-July 1,
1996
I. Clinical Topics.- The Clinical Profile of Sepsis and the Adult
Respiratory Distress Syndrome.- The Participation of the Complement
System in Atherosclerotic Vascular Disease.- The Spectrum of
Atherosclerosis in the Human.- Cerebral Endothelial Injury in
Stroke, Brain Trauma and Hypertension.- II. General Concepts in
Endothelial Cell Pathophysiology.- Free-Radical Mediated Actions on
Endothelial Cells of the Intact Lung.- Regulation of Vascular
Function by Vascular Permeability Factor.- III. Chemical Mediators
of Endothelial Cell Injury.- Endothelial Cells as Targets for and
Producers of Cytokines.- Roles of Vascular Cells in Inflammation
and Immunopathology.- The Biochemistry, Cell and Molecular Biology
of Type 1 Plasminogen Activator Inhibitor.- IV. Endothelial Cell
Interaction with Blood Components.- Purine Regulation of
Endothelial Cells: Relevance to Pathophysiology.- Autoantibodies to
Endothelial Cells.- Leukocyte-Endothelial Cell Interactions.- V.
Vascular Responses to Endothelial Cell Injury.- Endothelial
Function in Human Coronary Bypass Grafts.- Altered Renovascular
Endothelial Functions During Nephrotoxicity.- Cerebral Endothelial
Function: Physiology and Pathophysiology.- Mechanisms of Altered
Reactivity in the Cerebral Microcirculation.- VI. Mechanisms of
Endothelial Cell Dysfunction.- The Role of Apolipoprotein E and
Apolipoprotein B in Atherosclerosis.- Endothelial Cell-Matrix
Interactions in Health and Disease.- Biosynthesis and Assembly of
von Willebrand Factor by Vascular Endothelial Cells: Relevance to
Pathophysiology.- VII. Markers of Endothelial Cell Injury and
Repair.- Monitoring of Endothelial Plasmalemmal Ectoenzyme Function
as an Index of Endothelial Injury and Repair.- Pathophysiological
Significance of Endothelial Cell Integrins.- VIII. Epilogue.-
Vascular Endothelium: Physiological Basis of Clinical Problems.-
IX. Abstracts of Oral and Poster Presentations.- X. List of
Participants.- XI. Index.
This book is a compilation of the lectures and oral and poster
communications presented at the Advanced Study. Institute on
"Vascular Endothelium: Physiological Basis of Clinical Problems
II," which took place between June 20 and 30, 1992 in Rhodes,
Greece. This third in a series of ASIs on vascular endothelium
continued on the theme of the first (1988) ASI on "Receptors and
Transduction Mechanisms" and particularly expanded that of the 1990
conference on ''Physiological Basis of Clinical Problems. " We
continued the successful practice of bringing together clinicians
and scientists: this was reflected equally well in the composition
of the organizing committee as in the background of the
particiJ?ants. Endothelial cell functions and dysfunctions present
as many challenges to the mvestigator as they do to the curious
clinical practitioner. As these problems are necessarily different,
this unique ten-day co-habitation of these individuals continued to
offer fresh outlooks to each, stimulated potential collaborative
efforts and, most importantly, advanced --ever so slightly--our
knowledge of vascular biology. This year's conference was further
enriched by the presence of several of our colleagues from Eastern
Europe whom we are delighted to welcome as officially sponsored
participants to this and future NATO-supported meetings. It is
never superfluous to remind readers and participants that those
signing at the bottom of this page, while responsible for many of
the ASI's and the book's deficiencies, are but three of the many
contributors to the successes.
Proceedings of a NATO ARW held in Crete, Greece, June 22-July 1,
1996
This monograph contains the proceedings from the Advanced Study
Institute on "Vascular Endothelium: Physiological Basis of Clinical
Problems" which took place in Corfu, Greece in June 1990. The
meeting consisted of twenty-eight lectures, most of them adapted as
full length papers in this volume, as well as numerous short oral
and poster communications which are abstracted and also included in
alphabetical order (pages 239-302). There were ninety-six
participants from ten NATO and four other European countries. The
meeting was the second in as many years dealing with a specific
subject in Endothelial Cell biology. Following the 1988 discussion
on "Receptors and Transduction Mechanisms", the present ASI
recognized and tried to deal with the increasing overlap in
interest between basic scientists studying endothelial cell
functions and clinicians facing problems of known or suspected
endothelial pathological involvement. As with any similar effort,
we opted to be selective, rather than fail by trying to be
inclusive, in the subjects covered. We chose to discuss diseases,
such as atherosclerosis, sepsis, ARDS and stroke, based on their
relevance to endothelial cell function and urgent need for new
insights into their pathogenesis and treatment. Similarly, we
examined endothelial cell functions by considering their relevance
to disease and their potential for elucidating important
pathologies. Obviously, some areas were covered superficially or
not at all; this should not distract from their importance, but
rather reflect on the constraints of time and -not at all
negligibly -the bias of the organizing committee.
This monograph contains the contributions to the NATO Advanced
Studies Institute on "Vascular Endothelium: Responses to Injury",
which took place in Crete, Greece from June 18 to 27, 1994. This
was the fourth in the series of NATO-supported ASIs in selected
specific areas of endothelial cell biology, which began in 1988.
Each time, it has combined clinical with basic scientists and
renowned experts with novices in the field, in an attractive
setting conducive to dissemination of knowledge, high quality
discussions and exchange of ideas. This, as well as previous ASIs,
reflects the hard work of numerous people. As Co- Directors, we
have been particularly fortunate to benefit from the expert advice
of the Organizing Committee, which included Elizabetta Dejana,
Alberto Mantovani and Magdi Yacoub. Their insightful suggestions
helped formulate the scientific program of the ASI. We are also
grateful for the work and dedication of the local organizing
committee of Thomie Douraki, Stylianos Orfanos, Panayotis Behrakis,
Michael Maragoudakis and Lydia Argyropoulos who tirelessly looked
after the main details necessary to ensure that all of us enjoyed
the meeting. Similarly, we wish to thank Jim Parkerson, Connie
Snead, Andreas Papapetropoulos and Nandor Marczin for their
assistance in various aspects of the many preparations for the
conference. A very special thanks goes to Annie Cruz, the ASI Co-
ordinator, for her efficient, solicitous and pleasant demeanor
during the months prior to the ASI and especially during the ten
days of the conference.
This volume explores the various molecular pathways via which
endothelial cells communicate among them as well as with other
vascular cells (e.g., smooth muscle cells, leukocytes, platelets,
fibroblasts, etc.) in order to transduce physiologic and pathologic
signals. The most important pathologies discussed are: - pulmonary
vascular diseases - thrombosis - hypertension (systemic and
pulmonary) - inflammation - angiogenesis - cerebrovascular disease
- transplantation - atherosclerosis. The largest fraction of time
was devoted to the mechanisms and signals underlying these
diseases.
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