Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

"When I sat down to read this book, I decided to fasten my seat-belt. There are people so desperate that they are willing to commit terrible crimes to get their message across, and there are carers so assaulted that they must put safety before care. Not a book to read before bedtime you might say. However I'm not sure that this is setting the scene correctly, because, when I read it, in addition to the psychopathology of desperation, there is the capacity to reflect on it, and to give despair the meaning it should have, and to do so with a greatly reassuring power."--From the Foreword by Bob Hinshelwood, Member of the British Psychoanalytic Society, Fellow of the Royal College of Psychiatrists and Professor in the Centre for Psychoanalytic Studies, University of Essex, UK "[The book] may stand as an unusually bold and uncompromising example of psychodynamically informed action research and the contribution this can offer, drawing on the intelligence afforded by emotional experience, to the restoring of both meaning and agency. Viewed in this way, the book both speaks to and has a relevance for practitioners, managers and consultants well beyond the boundaries of just one signal enterprise."--From the Afterword by David Armstrong, Principal Consultant at the Tavistock Consultancy Service, the Tavistock and Portman NHS Foundation Trust

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below)."

Ecosystem management has gained widespread visibility as an approach to the management of land to achieve sustainable natural resource use. Despite widespread interest in this emerging management paradigm, Ecosystems: Balancing Science with Management is the first book to directly propose approaches for implementing ecosystem management, give examples of viable tools, and discuss the potential implications of implementing an ecosystem approach. These ideas are framed in a historical context that examines the disjunction between ecological theory, environmental legislation and natural resources management.