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Concepts in Toxicology (Hardcover)
John H. Duffus, Douglas M Templeton, Monica Nordberg; Contributions by Iupac, John W. Lorimer
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R1,803
Discovery Miles 18 030
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Ships in 12 - 17 working days
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Toxicology has never been more important. Advances in chemistry and
technology offering improvements in the quality of human life
become ever more rapid, bringing with them the potential for new
toxicity hazards. This has led to legislation requiring toxicity
testing and risk assessment for all chemicals and their uses. The
new REACH (Risk Evaluation and Authorization of Chemicals)
Regulation has profound economic consequences because, without
official authorization, a chemical cannot be marketed. This book
explains, in depth, the ideas underlying current advances in
toxicology and its application in regulating and ensuring the safe
use of chemicals. Sometimes old ideas have become assumptions that
have become embedded in related laws and regulation, even though
the thinking of toxicologists has moved on in line with
developments in science. This leads to confusion in public
understanding that the book should dispel. There are also
fundamental ideas in toxicology that are not well understood
concerning the concepts of hazard and risk and even about what
constitutes a chemical. For many people the word 'chemical'
describes manmade substances only. In fact, it is correctly applied
to all substances that exist, from pure elements to the most
complex biological molecules in food and medicines. This is further
complicated by the complex distinction between the descriptors,
'toxic' and 'nontoxic'. Developments in epigenetics are
revolutionizing our understanding of mutagenicity and
carcinogenicity. Improved understanding of apoptosis and necrosis
leads to improved interpretation of potentially toxic effects at
the cellular level. The recently defined term 'chemical speciation'
is driving more targeted research on the toxicity of inorganic
chemicals. This book explains the concepts implied by key
toxicological terms using diagrams to illustrate the relationships
between them. It is an essential aid to understanding the new
demands from regulators of risk assessment and to the
implementation of appropriate risk management.
Fundamental Toxicology is a concise and comprehensive review of
toxicology. It is based on the highly successful Fundamental
Toxicology for Chemists and has been enriched and expanded. Every
chapter in this new edition has been revised and updated, and four
new chapters have been added. With contributions from
internationally recognised experts in their field, this broad-based
introduction to the topic covers both well-established and rapidly
developing areas of toxicology, such as toxicogenomics,
reproductive toxicology, behavioural toxicology and ecotoxicology.
The book was written and published with the support of the
International Union of Pure and Applied Chemistry (IUPAC). The book
includes new information on: risk assessment and risk management;
toxicogenomics; effects of toxic substances on the human body;
environmental distribution of chemicals and ecotoxicology; clinical
toxicology; pharmaceutical toxicology; and aspects of laboratory
measurement and safe laboratory practice. Fundamental Toxicology is
ideal for students and includes extensive pedagogical features,
such as an extensive glossary, a bibliography after each chapter
and recommended further reading. It is also designed for teachers
and lecturers, especially those who may be teaching toxicology for
the first time. Included is a suggested curriculum for using the
text to teach toxicology to students from various scientific
disciplines. Professionals working in toxicology and related fields
will find this an invaluable guide.
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