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Lipids traditionally have been viewed as serving two functions: to
form cellular membranes and to serve as energy stores. During the
last two decades, a new role for lipids has taken center stage:
lipids can act as signalling molecules. This book deals with a
variety of lipids that have been shown to be messengers. Leading
scientists explore all known lipid classes except steroid hormones.
Researchers and educators in biochemistry as well as in molecular
and cellular biology will appreciate this volume.
Scientists in lipid biochemistry research have increasingly
recognized the role of lipids as signaling molecules, aside from
their importance in forming cellular membranes and storing energy.
This book provides the latest findings on a wide variety of complex
lipids in cells that function either as intracellular or
intercellular messengers. International investigators present
current data on the most extensively studied examples of both
intracellular and intercellular messengers generated from lipids,
and describe their basic mechanisms, which also utilize receptors
in the G-protein-coupled family. The in-depth discussions address
such topics as lipid signaling for protein kinase C activation,
phosphatidic acid and lyso-phosphatidic acid, ceramide as a
messenger, bioactive properties of Sphingosine and structurally
related compounds, platelet-activating factor and PAF-like
mimetics, and prostaglandins and related compounds. Lipid Second
Messengers is an up-to-date reference on developments in the
expanding field of lipid-derived signals and will be of interest to
biochemists, physiologists, pharmacologists, geneticists, and
biologists.
"Crucible of Science" is the story of a unique laboratory at
Washington University in St. Louis, and of Carl and Gerty Cori, the
biochemists who established it. Carl and Gerty met and married at
medical school in Prague in the 1920s. After graduation, they
immigrated to the U.S. to escape deteriorating conditions in
Europe. Carl soon received an offer from Washington University to
become Pharmacology Chair, and the couple settled in St. Louis. Not
only did both Coris go on to win the Nobel Prize, the laboratory
they established at the University has since produced some of the
most outstanding scientists the U.S. has ever seen. Six laboratory
scientists also won Nobel Prizes; few, if any, laboratories can
claim such an impressive record. The Coris themselves were
instrumental in establishing the then new science of Biochemistry
in the U.S. They applied chemical approaches to elucidating the
transformations of compounds such as glucose in animal tissues and
defined the enzyme BIOL15GENRthat carried out those
transformations. Both scientists were extremely rigorous in
designing their experiments and interpreting the results, a habit
that ensured their findings were above question. This book examines
the careers of both Coris and the other eminent scientists who
trained in their laboratory. It notes the Coris' acceptance of
women, Jews, and scientists from all over the world, unique during
this time period. It analyzes those reasons why the laboratory was
so successful in attracting the best trainees and producing premier
scientists. Intended for scientists, science historians, and anyone
interested in the history of science, "Crucible of Science" is a
unique presentation of remarkable careers and personalities,
examined within the context of the Coris' laboratory.
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