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The Wiggers Bernard Conferences, named after two great
physiologists of the past, are an nual gatherings of the leaders in
the field of shock. The meetings focus on specific areas of which
appears to be showing the most advancement during the previous
year. There are se veral types of sessions; informal presentations
during which the seminarian can be intenup ted in order to clarify
a particular point; formal discussions follow each presentation;
these are followed by informal gatherings in which these
discussions continue during meals and libation in a very relaxed
environment. The 1990 meeting took place in Durnstein, Austria. A
small hamlet in the wine growing area of the Wachau valley, on the
Danube above Vien na. This was the site of a former citadel where
the English King Richard the Lion-Heart (Coeur de Uon) was held for
ransom during the middle ages. The frank beauty and hospi tality of
this area in addition to the ancient Roman adage "in vino veritas"
acted as a catalyst to crystalize the thoughts of this
interdisciplinary group of scientists as they discussed the
following areas: 1. Gut as a Source of Organ Failure 2. Metabolic
Aspects of the Liver in Sepsis 3. Endothelium as a Target'in Sepsis
We would like to thank the participants of the conference for
taking time away from their very productive and busy schedules to
participate in the conference and for the prompt pre sentation of
their manuscripts and editions of their discussions.
The First Wiggers Bernard Conference on Shock, Sepsis, and Organ
Failure was envisaged as a meeting of American and European
Scientists. It was named after two researchers, one from the "Old"
and one from the "New World," who are wellknown for their
outstanding achievements in shock research and experimental
medicine. This meeting was a point of de parture for a series of
workshops that will focus on two to three main topics dealt with in
detail by experts in their respective fields. The First Wiggers
Bernard Conference addressed three main questions: 1.
Multi-organ-failure - is it a sequence of organ failures or a
systemic disease? 2. Cellular events in trauma and sepsis - are
they due to suppression, activation or both? 3. Mediators of organ
failure - are LPS or sepsis necessary? Although many answers were
given in this first session, numerous issues remain to be clarified
due to the enormous complexity of the subject. How ever, the stage
was set for encounters between clinicians and basic medical
researchers, since theoretical knowledge will be useful to the
clinician ex ploring new approaches to diagnosis, prophylaxis, and
therapy. The conference could not have been organized without the
generous sup port of the Immuno Company, Vienna, Austria. May we
express our special thanks to Dr. Eibl, managing director and head
of the research division of Immuno AG, not only for granting
financial support but also for his valuable advice, encouragement,
and scientific expertise."
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