Focusing on new 3-D "in vitro" methods, this book brings together examples of leading-edge work being conducted internationally for improving "in vitro" cell culture methods. It highlights the use of systems for enabling cell culture under laminar flow and the use of 3-D scaffolds for providing cells with a structure which replicates the function of the extracellular matrix and encouraging interactions more akin to an in vivo environment. Chapters cover state-of-the-art protocols for bioreactor systems, in vitro toxicity methods, non-invasive imaging, 3-D cell cultures, stem cell usage, and the integration and use of novel scaffolds.