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The third edition of this innovative work again provides a unique
perspective on the clinical discovery process by providing input
from experts within the NIH on the principles and practice of
clinical research. Molecular medicine, genomics, and proteomics
have opened vast opportunities for translation of basic science
observations to the bedside through clinical research. As an
introductory reference it gives clinical investigators in all
fields an awareness of the tools required to ensure research
protocols are well designed and comply with the rigorous regulatory
requirements necessary to maximize the safety of research subjects.
Complete with sections on the history of clinical research and
ethics, copious figures and charts, and sample documents it serves
as an excellent companion text for any course on clinical research
and as a must-have reference for seasoned researchers.
Incorporates new chapters on Managing Conflicts of Interest in
Human Subjects Research, Clinical Research from the Patient's
Perspective, The Clinical Researcher and the Media, Data Management
in Clinical Research, Evaluation of a Protocol Budget, Clinical
Research from the Industry Perspective, and Genetics in Clinical
ResearchAddresses the vast opportunities for translation of basic
science observations to the bedside through clinical researchDelves
into data management and addresses how to collect data and use it
for discoveryContains valuable, up-to-date information on how to
obtain funding from the federal government
Principles and Practice of Clinical Research, Fourth Edition has
been thoroughly revised to provide a comprehensive look at both the
fundamental principles and expanding practice of clinical research.
New to this edition of this highly regarded reference, authors have
focused on examples that broadly reflect clinical research on a
global scale while including a discussion of international
regulations, studies, and implications. In addition to key topics
such as bioethics, clinical outcome data, cultural diversity,
protocol guidelines, and "omic" platforms, this edition contains
new chapters devoted to electronic health records and information
resources for clinical researchers, as well as the many
opportunities associated with big data. Covering a vast number of
topics and practical advice for both novice and advanced clinical
investigators, this book is a highly relevant and essential
resource for all those involved in conducting research.
Emerging Infections is a reprint of the inaugural volume of the
thematic serial, "Biomedical Research Reports Series" that provides
annual updates on hot topics of interest to a broad spectrum of the
biomedical research community. This volume provides
state-of-the-art reviews of the most important "new" and reemerging
bacterial, viral, and parasitic infections, their life cycles, host
defense evasion strategies, and clinical features. Emerging
Infections includes in-depth coverage of the history of infectious
disease outbreaks, population and evolutionary biology of human
pathogens, and current epidemiological models that describe how
ecological and demographic changes produce new epidemics. The book
covers the major established pathogens as well as the new and
sensational--mad cow disease, hantavirus pulmonary syndrome,
pathogenic "E-coli, " and flesh-eating bacteria.
Key Features
* Discusses persisting problems in tuberculosis
* Covers pathogenic escherichia colo 0157: H7
* Explains the revival of Group A Streptococcal diseases
* Provides information on antibiotic resistance in bacteria
* Includes coverage of Korean hemorrhagic fever and hantavirus
pulmonary syndrome
* Questions where the Ebola virus comes from and where is it going
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