Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention. This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.

The world-wide sales of polysiloxanes or silicones at the beginning of this new millennium is approximately $10 billion per year. Commercial products range from those entirely composed of silicone to products where the silicone is a low level but key component. This symposium covered the recent academic and technological developments behind silicones and silicone-modified materials and the sessions were well attended of wide interest to both the academic and industrial communities. The papers from our two highly successful symposia in this important area were published in the books Silicones and Silicone-Modified Materials, (Eds. S. J. Clarson, J. J. Fitzgerald, M. J. Owen and S. D. Smith), ACS Symposium Series Vol. 729 / Oxford University Press, 2000, ISBN 0-8412-3613-5 and Synthesis and Properties of Silicones and Silicone-Modified Materials, (Eds. S. J. Clarson, J. J. Fitzgerald, M. J. Owen, S. D. Smith and M. E. Van Dyke), ACS Symposium Series Vol 838 / Oxford University Press, 2003, ISBN 0-8412-3804-9

Collection of four children's animated features. In 'Home On the Range' (2004), when an eviction notice goes up at the Little Piece of Heaven family-run dairy farm, notorious yodelling outlaw cattle rustler Alameda Slim (voice of Randy Quaid) sees his big chance to claim it for himself. However, he hasn't counted on three resourceful dairy cows, old-timer Mrs Calloway (Judi Dench), tough-talking Maggie (Roseanne Barr) and gentle Grace (Jennifer Tilly), who enlist the help of the other farm animals to track down Slim and use the ransom on his head to save their beloved farm. But the bovine trio have another enemy to contend with - ruthless bounty hunter Rico (Charles Dennis) is also after the reward for capturing Slim. 'G-Force' (2009) follows a team of secret agent guinea pigs who have been trained in espionage techniques and armed with the latest high-tech spy equipment in order to take on a covert mission for the US government. The team, known by code name 'G-Force', includes ambitious squad leader Darwin (Sam Rockwell), fearless weapons expert Blaster (Tracy Morgan) and lithe martial arts genius Juarez (Penélope Cruz). Also along for the ride is Darwin's housefly sidekick Mooch and computer whiz Speckles (Nicolas Cage), a star-nosed mole. Can the gang prevent an evil billionaire from taking over the world with a dastardly plan involving household appliances? In 'The Wild' (2006) an odd assortment of animals from the New York Zoo discover what a jungle the city can be when one of their own is mistakenly shipped to the wild. When an adolescent lion (Greg Cipes) is accidentally shipped from the zoo to Africa, his pals, including Samson the lion (Kiefer Sutherland), Benny the squirrel (James Belushi), Bridget the giraffe (Janeane Garofalo), Larry the anaconda (Richard Kind), Kazar the wildebeest (William Shatner) and Nigel the koala bear (Eddie Izzard), must put aside their differences to help bring him back. In 'Beverly Hills Chihuahua' (2008), when pampered Beverly Hills chihuahua Chloe (Drew Barrymore) gets lost while holidaying in Mexico, she is forced to rely on the kindness of various dogs she befriends as she tries to get home before she is captured by a villainous dognapper. Also in pursuit of Chloe is male chihuahua Papi (George Lopez), who is in love with her, and evil Doberman Diablo (Edward James Olmos), who has his eye on her valuable diamond collar.

No business, legitimate or otherwise, has had a more raucous influence on the history of a city than that of the Outfit in Chicago. From the roots of organized crime in the late 19th century to the present day, The Chicago Outfit examines the evolution of the city's underworld, focusing on their business activities and leadership along with the violence and political protection they employed to become the most successful of the Cosa Nostra crime families. Through a vivid and visually stunning collection of images, many of which are published here for the first time, author John Binder tells the story of the people and places of the world of organized crime from a fresh and informed point of view.

Psychological thriller set in the American ballet world starring Natalie Portman in an award-winning performance. Nina (Portman) is a dancer in a New York City ballet company. Still living with her domineering and obsessive mother Erica (Barbara Hershey), a former ballerina herself, Nina barely has a life outside her dancing. When the company's artistic director Thomas Leroy (Vincent Cassel) decides to replace prima ballerina Beth MacIntyre (Winona Ryder) for a major new production of Swan Lake, Nina finds herself losing sight of her own identity as she becomes caught up in a twisted competitive friendship with her rival Lily (Mila Kunis). Portman won the 2011 Golden Globe, BAFTA and Academy Award for Best Actress.

Elgar Research Agendas outline the future of research in a given area. Leading scholars are given the space to explore their subject in provocative ways, and map out the potential directions of travel. They are relevant but also visionary. Authoritative and multidisciplinary in approach, this Research Agenda shapes questions that will underpin future legal and empirical scholarly inquiry on zoning and land use regulation in the US. Building on existing debates and providing a comprehensive overview of the current state of academic research, it identifies the gaps which need addressing in future research. Bringing together a diverse array of prominent voices across multiple disciplines, A Research Agenda for US Land Use and Planning Law adeptly navigates central themes including the structure of land use regulation, the relationship between zoning and planning, and the role of different levels of government and administrative agencies. Chapters critically analyse the laws that govern public participation alongside the potential reforms to these processes. A number of pressing issues are rigorously examined, including housing, historic preservation, sustainability and climate change, transportation, declining cities, residential segregation, and the relationship between private and public land use controls. This accessible and progressive Research Agenda will be of great interest to scholars and graduate students interested in planning, zoning, urban economics, property law, environmental law, legal studies, and political science. Practitioners looking for insightful analysis of seminal literature will similarly find this to be a beneficial read.

The Maine Woods, vast and largely unsettled, are often described as unchanged since Henry David Thoreau's 1847 journey across the backcountry, in spite of the realities of Indian dispossession and the visible signs of logging, settlement, tourism, and real estate development. In the summer of 2014 scholars, indigenous peoples, activists, and other individuals retraced Thoreau's route. Inspired partly by this expedition, the accessible and engaging essays here offer valuable new perspectives on conservation, the cultural ties that connect Native communities to the land, and the profound influence the geography of the Maine Woods had on Thoreau and writers and activists who followed in his wake. Together, these essays offer a rich and multifaceted look at this special place and the ways in which Thoreau's Maine experiences continue to shape understandings of the environment a century and a half later. Contributors include the volume editor, Kathryn Dolan, James S. Finley, James Francis, Richard W. Judd, Dale Potts, Melissa Sexton, Chris Sockalexis, Stan Tag, Robert M. Thorson, and Laura Dassow Walls.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.