Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Women's Entrepreneurship in the 21st Century: An International Multi-Level Research Analysis is the fourth in the series of books produced in partnership with the Diana International Research Network. The volume takes a multi-dimensional approach to the central theme of gender and entrepreneurship today and in the future.The book takes a holistic approach to exploring, via empirical and theoretical lenses, why women's involvement in venture creation matters. It offers a contemporary and diverse range of topics, written by leading scholars, that builds on a tradition of previous Diana volumes. The chapters span a wide range of countries, methodologies, and levels of analysis, all designed to contribute to advancing understanding of women and their engagement with entrepreneurial endeavors. With its broad span of geographic relevance and research driven by empirical data, this book will prove an essential guide for academics, students and researchers in the field, as well as policymakers and practitioners. Contributors: C.G. Brush, J. Byrne, S. Chasserio, S. Coleman, J. Courvisanos, A. de Bruin, M. Dlouha, T. Esnard, S. Fattoum, H. Frederick, J. Gabrielsson, E.J.Gatewood, R.T. Harrison, C. Henry, K. Ibata-Arens, M. Jomaraty, N. Jurik, A. K i kova, T. Lebegue, C.M. Leitch, K.V. Lewis, A.L. Dahlstrand, E. Lisowska, D. Mo nik, C. Nguyen, H. Nguyen, D. Politis, C. Poroli, A. Robb, N. Sappleton, K. irec, J. Watson, F. Welter

Considering the epidemiology of COPD, this title collects all available knowledge on the subject, featuring data on the national emphysema treatment trial. It explores the epidemiology of emphysema, the management of complications and surgical controversies in lung volume reduction surgery for emphysema (LVRS).

For decades, scholars have disagreed about what kinds of behavior count as crime. Is it simply a violation of the criminal law? Is it behavior that causes serious harm? Is the seriousness affected by how many people are harmed and does it make a difference who those people are? Are crimes less criminal if the victims are black, lower class, or foreigners? When corporations victimize workers is that a crime? What about when governments violate basic human rights of their citizens, and who then polices governments? In What Is Crime? the first book-length treatment of the topic, contributors debate the content of crime from diverse perspectives: consensus/moral, cultural/relative, conflict/power, anarchist/critical, feminist, racial/ethnic, postmodernist, and integrational. Henry and Lanier synthesize these perspectives and explore what each means for crime control policy.

Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials.

The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future.

Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed.

Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, "Critical Pathways to Success in CNS Drug Development"is full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations

One of the most influential and compelling books in American literature, Walden is a vivid account of the years that Henry D. Thoreau spent alone in a secluded cabin at Walden Pond. This edition--introduced by noted American writer John Updike--celebrates the perennial importance of a classic work, originally published in 1854. Much of Walden's material is derived from Thoreau's journals and contains such engaging pieces from the lively "Where I Lived, and What I Lived For" and "Brute Neighbors" to the serene "Reading" and "The Pond in the Winter." Other famous sections involve Thoreau's visits with a Canadian woodcutter and with an Irish family, a trip to Concord, and a description of his bean field. This is the complete and authoritative text of Walden--as close to Thoreau's original intention as all available evidence allows. This is the authoritative text of Walden and the ideal presentation of Thoreau's great document of social criticism and dissent.

In its narrowest sense, "mentally disordered offender" refers to the approximately twenty thousand persons per year in the United States who are institutionalized as not guilty by reason of insanity, incompetent to stand trial, and mentally disordered sex offenders, as well as those prisoners transferred to mental hospitals. The real importance of mentally disordered offenders, however, may not lie in this figure. Rather, it may reside in the symbolic role that mentally disordered offenders play for the rest of the legal system. The 3,140 persons residing in state institutions on an average day in 1978 as not guilty by reason of insanity (see Chapter 4), for example, are surely worthy of concern in their own right. But they represent only 1% of the 307,276 persons residing in state and federal prisons in the same period (U. S. Dept. of Justice, 1981). From a purely numeric point of view, the insanity defense truly is "much ado about little" (Pasewark & Pasewark, 1982). The central importance of understanding these persons, however, is that they serve a symbolic function in justifying the imprisonment of the other 99%. The insanity defense, as Stone (1975) has noted, is "the exception that proves the rule. " By exculpating a relatively few people from being criminally responsible for their behavior, the law inculpates all other law violators as liable for social sanction.

This book is formulated from the papers presented at the International Symposium on "Membrane Biochemistry and Bioenergetics," held at the Rensselaerville Institute, Rensselaerville, New York, August 1986, in honor of Tsoo E. King on the occasion of the 30th anniversary of reconstitution of arespiratory chain system by Professor David Keilin and Tsoo E. King. Professor Tsoo E. King, to whom this volume is dedicated, has made enormous contributions to the field of isolation and reconstitution of membrane proteins and has continued to explore the frontiers of bioener getics. In particular, his persistent proposals on the existence of ubiquinone binding proteins from conceptualization to experimentation eventually convinced many scientists to study these proteins further . Professor King's preparation of reconstitutively active succinate dehydrogenase opened a new avenue in the fie1d of membrane bioenergetics, and his work has been greatly appreciated. The purpose of the symposium was to bring together scientists from diverse disciplines related to membrane bioenergetics to discuss the recent developments in the field. This symposium, initiated by the Capital District Bioenergetics Group, was attended by 100 scientists, 80 of whom presented their recent discoveries. The symposium was arranged in a sequence of platform lectures, poster presentations and discussion sessions so that all the participants had opportunities to discuss the subjects presented. Most of the participants contributed a chapter to this volume. We would like to express our regret to many other scientists including Professor King's friends, colleagues and students who could not attend due to various reasons."

In its narrowest sense, "mentally disordered offender" refers to the approximately twenty thousand persons per year in the United States who are institutionalized as not guilty by reason of insanity, incompetent to stand trial, and mentally disordered sex offenders, as well as those prisoners transferred to mental hospitals. The real importance of mentally disordered offenders, however, may not lie in this figure. Rather, it may reside in the symbolic role that mentally disordered offenders play for the rest of the legal system. The 3,140 persons residing in state institutions on an average day in 1978 as not guilty by reason of insanity (see Chapter 4), for example, are surely worthy of concern in their own right. But they represent only 1% of the 307,276 persons residing in state and federal prisons in the same period (U. S. Dept. of Justice, 1981). From a purely numeric point of view, the insanity defense truly is "much ado about little" (Pasewark & Pasewark, 1982). The central importance of understanding these persons, however, is that they serve a symbolic function in justifying the imprisonment of the other 99%. The insanity defense, as Stone (1975) has noted, is "the exception that proves the rule. " By exculpating a relatively few people from being criminally responsible for their behavior, the law inculpates all other law violators as liable for social sanction.

New essays by leading scholars on the most perplexing of modern writers, Franz Kafka. No other 20th-century writer of German-language literature has been as fully accepted into the canon of world literature as Franz Kafka. The unsettlingly, enigmatically surreal world of Kafka's novels and stories continues to fascinate readers and critics of each new generation, who in turn continue to find new readings. One thing has become clear: although all theories attempt to appropriate Kafka, there is no one key to his work. The challenge to criticshas been to present a strong point of view while taking account of previous Kafka research, a challenge that has been met by the contributors to this volume. Contributors: James Rolleston, Clayton Koelb, Walter H. Sokel, Judith Ryan, Russel A. Berman, Ritchie Robertson, Henry Sussman, Stanley Corngold, Bianca Theisen, Rolf J. Goebel, Richard T. Gray, Ruth V. Gross, Sander L. Gilman, John Zilcosky, Mark Harman James Rolleston is Professor Emeritus of German at Duke University.

Essential aspects about the prehistory, history, geography, and architecture of the Inland Pacific Northwest are presented here in one succinct volume. This landmark collection features essays by noted national and regional scholars, such as Donald W. Meinig, Carlos A. Schwantes, Henry Matthews, Clifford E. Trafzer, and Harvey S. Rice. Spokane and the Inland Empire outlines the region's historical geographic systems, Palouse tribal history, characteristics of prehistoric Plateau Indian dwellings, a century of Columbia Plateau agriculture, Spokane's bitter labor disputes that occurred prior to America's entry into World War I, the exceptional architecture of Spokane's Kirtland Cutter, and more. This new edition has been revised from the original volume published in 1991. Extensive illustrations supplement the text.

Excerpt from Conference Address One of the most complex and significant social issues facing our nation is reform of our national health system. I am personally committed, and Goodyear Tire & Rubber is committed, to doing everything we can to help improve that system while simultaneously gaining some measure of control over the tremen dous rate of cost escalation. I feel very strongly that in the months ahead, business leaders must become actively involved in a concerted effort to strike a balance between our desire to assure the best medical care for all and the reality of doing so at a cost our society can afford. For the past two years I have been chairman of the Business Roundtable's Task Force on Health and in that capacity have been working closely with the Washington Business Group on Health. Through this exposure and the encour aging results of Goodyear's own cost containment activities, I was asked to serve on HEW Secretary Califano's Advisory Committee on National Health Insurance. This committee, representing a broad spectrum of interests and expertise, will be meeting in cities across the country and will hold hearings in Washington before entering into final discussions with HEW and other admin istration officials. The result of its work is to be combined with that of the HEW staff in formulating the basis of President Carter's national health insurance proposal."