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This authoritative volume explores advances in the techniques used
to measure percutaneous penetration of drugs and chemicals to
assess bioavailability and bioequivalence and discusses how they
have been used in clinical and scientific investigations. Seven
comprehensive sections examine topics including in vitro drug
release, topical drugs products, clinical studies, and guidelines
and workshop reports, among others. The book also describes how
targeted transdermal drug delivery and more sophisticated
mathematical modelling can aid in understanding the bioavailability
of transdermal drugs. The first edition of this book was an
important reference guide for researchers working to define the
effectiveness and safety of drugs and chemicals that penetrated the
skin. This second edition contains cutting-edge advances in the
field and is a key resource to those seeking to define the
bioavailability and bioequivalence of percutaneously active
compounds to improve scientific and clinical investigation and
regulation.
This authoritative volume explores advances in the techniques used
to measure percutaneous penetration of drugs and chemicals to
assess bioavailability and bioequivalence and discusses how they
have been used in clinical and scientific investigations. Seven
comprehensive sections examine topics including in vitro drug
release, topical drugs products, clinical studies, and guidelines
and workshop reports, among others. The book also describes how
targeted transdermal drug delivery and more sophisticated
mathematical modelling can aid in understanding the bioavailability
of transdermal drugs. The first edition of this book was an
important reference guide for researchers working to define the
effectiveness and safety of drugs and chemicals that penetrated the
skin. This second edition contains cutting-edge advances in the
field and is a key resource to those seeking to define the
bioavailability and bioequivalence of percutaneously active
compounds to improve scientific and clinical investigation and
regulation.
Despite ongoing efforts to prohibit the production, storage and use
of chemical warfare agents recent world events highlight the
enduring threat to the population from these agents. Research
efforts in various countries have resulted in novel insights into
chemical warfare toxicology that has enabled the development of new
approaches for the diagnosis and treatment of chemical warfare
poisoning. This two-volume set provides an up-to-date treatise on
the ongoing research into the toxicology of chemical warfare
agents, the diagnosis and verification of exposure, and the pre-
and post-exposure treatment of poisoning. Focussing on the most
important representative nerve and blistering agents, whilst also
covering other potential chemical warfare agents, these books will
give the reader a comprehensive overview of the many different
aspects of chemical warfare agent toxicology. The texts will appeal
to toxicologists, biochemists and weapons specialists working in
industry and academia, and anyone with an interest in chemical
warfare toxicology or exposure.
Despite ongoing efforts to prohibit the production, storage and use
of chemical warfare agents recent world events highlight the
enduring threat to the population from these agents. Research
efforts in various countries have resulted in novel insights into
chemical warfare toxicology that has enabled the development of new
approaches for the diagnosis and treatment of chemical warfare
poisoning. This book provides an up-to-date treatise on the
diagnosis and verification of exposure, and the pre- and
post-exposure treatment of poisoning. Focussing on the most
important representative nerve and blistering agents, whilst also
covering other potential chemical warfare agents, this book will
give the reader a comprehensive overview of the many different
aspects of chemical warfare agent toxicology. The text will appeal
to toxicologists, biochemists and weapons specialists working in
industry and academia, and anyone with an interest in chemical
warfare toxicology or exposure.
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