The objective of this book is to provide the researcher and clinician with the recent developments in the analysis and assessment of cardiovascular func tion. The chapters are organized into sections that correspond with the various anatomical levels of the cardiovascular system. To a large extent, recent focus on the cardiovascular system function has been directed at the molecular level to the near exclusion of the tissue and organ function. While this may be useful in developing new therapeutic drugs, it does not aid the cardiologist or surgeon, who routinely deal with patient symptoms. This book integrates the micro-level and organ-level function so that new infor mation may be assimilated into the cardiovascular system as a whole. Within each section, the chapters have been arranged to progress from recent theoretical developments, to experimental research, and finally to clinical applications. This approach facilitates the timely transfer of infor mation from basic research to the clinic. The strength of the analytical approach will be evident to the reader. The theoretical analysis offers guidance to experimental design and, in some cases, offers solutions where measurements are as yet unattainable. In moving from newly attained knowledge to clinical practice, this book emphasizes the noninvasive meth in the future as technological advances ods. Such methods are desirable occur and the trend towards early preventive diagnosis is sought. What follows are highlights of new developments covered in each section of the book."

After yet another decade of leaming, experimenting, and inves tigating since my first book, Arterial System Dynamics, the many new medical breakthroughs and technological advances have inspired me to write this book to bridge the gap between basic research and clinical applications. The application of physical principles and quantitative approaches to the understanding of the arterial circulation and its interactions with the heart in normal and diseased conditions form the basis of The Arterial Circulation. Knowledge of the physiology and rheology of arteries, as well as all of their structural-functional corre lates, is a necessary prerequisite to the proper hemodynamic interpretatiqn of pressure-flow relations and the pulsatile transmis sion characteristics in different arteries. The natural coupling and interactions of the heart, the coronary circulation, and the arterial system necessitate analysis of alterations to global functioning. Modeling provides a tool for isolating and predicting parameter changes and is employed throughout the book. Experimental data are provided for model validations, and also for more realistic interpretations. Techniques and new methods for clinical hemo dynamic measurement and diagnosis are included to help the reader un derstand the physical principles underlying such abnormal cardiovascular functions as hypertension, stenosis, and myocardial ischemia. The progressive changes in vascular properties during aging are also discussed. Modem approaches utilizing computer mode ling and allomery are presented with selected examples, such as combined hypertension and aortic valve stenosis, and ventricular hypertrophy."

The first edition of the book was written employing mathematical techniques to formulate the physical principles involved in the structural and functional correlates of the underlying physiology.This current and self-contained second edition updates many of the new findings since its first edition a decade ago. It also includes a new chapter on the 'Interaction with the Heart'. The dynamics of the arterial system, the venous system, the microcirculation and their interaction with the heart are quantitatively described in terms of their structures and functions. Clinical measurements, applications to the cardiovascular field and physiological mechanisms are clearly identified throughout the text. Most importantly, worked examples are provided, such that the readers can appreciate the application aspects of the underlying formulation.

Comparative Cardiovascular Dynamics of Mammals offers never-before-published data on the structure and function of the circulatory systems of the different mammalian species. This text explores classic allometry, dimensional analysis, and modern hemodynamics to establish similarity principles that provide a necessary and important step in understanding the natural common design and functional features of the cardiovascular systems of different mammals. Fluid and blood vessel mechanics, pulse transmission characteristics, cardiac energetics and mechanics, as well as heart-arterial system interaction are included in this essential reference. The sensitivity of parameters and similarity of principles in the diagnosis of cardiovascular diseases are also addressed. This book also describes the natural processes involved in the functional development of the mammalian cardiovascular system. By using modern methods to present recent findings on the similarities and differences of the mammalian cardiovascular system, the author provides an easily understood approach to this dynamic field of study.

After yet another decade of leaming, experimenting, and inves tigating since my first book, Arterial System Dynamics, the many new medical breakthroughs and technological advances have inspired me to write this book to bridge the gap between basic research and clinical applications. The application of physical principles and quantitative approaches to the understanding of the arterial circulation and its interactions with the heart in normal and diseased conditions form the basis of The Arterial Circulation. Knowledge of the physiology and rheology of arteries, as well as all of their structural-functional corre lates, is a necessary prerequisite to the proper hemodynamic interpretatiqn of pressure-flow relations and the pulsatile transmis sion characteristics in different arteries. The natural coupling and interactions of the heart, the coronary circulation, and the arterial system necessitate analysis of alterations to global functioning. Modeling provides a tool for isolating and predicting parameter changes and is employed throughout the book. Experimental data are provided for model validations, and also for more realistic interpretations. Techniques and new methods for clinical hemo dynamic measurement and diagnosis are included to help the reader un derstand the physical principles underlying such abnormal cardiovascular functions as hypertension, stenosis, and myocardial ischemia. The progressive changes in vascular properties during aging are also discussed. Modem approaches utilizing computer mode ling and allomery are presented with selected examples, such as combined hypertension and aortic valve stenosis, and ventricular hypertrophy."

The objective of this book is to provide the researcher and clinician with the recent developments in the analysis and assessment of cardiovascular func tion. The chapters are organized into sections that correspond with the various anatomical levels of the cardiovascular system. To a large extent, recent focus on the cardiovascular system function has been directed at the molecular level to the near exclusion of the tissue and organ function. While this may be useful in developing new therapeutic drugs, it does not aid the cardiologist or surgeon, who routinely deal with patient symptoms. This book integrates the micro-level and organ-level function so that new infor mation may be assimilated into the cardiovascular system as a whole. Within each section, the chapters have been arranged to progress from recent theoretical developments, to experimental research, and finally to clinical applications. This approach facilitates the timely transfer of infor mation from basic research to the clinic. The strength of the analytical approach will be evident to the reader. The theoretical analysis offers guidance to experimental design and, in some cases, offers solutions where measurements are as yet unattainable. In moving from newly attained knowledge to clinical practice, this book emphasizes the noninvasive meth in the future as technological advances ods. Such methods are desirable occur and the trend towards early preventive diagnosis is sought. What follows are highlights of new developments covered in each section of the book.