Biologist Margo Green (Penelope Ann Miller) teams up with police Lieutenant D'Agosta (Tom Sizemore) to investigate a series of grisly murders at her place of work - the Natural History museum. Can there be a link with the recently-arrived crates belonging to a missing anthropologist from Brazil? All that is found in the crates are some leaves covered with a strange fungus, which when analysed proves capable of mutating whoever eats it. When a guard is killed and a headless body interrupts the museum's exhibition gala, Margo and D'Agosta discover that there is an ancient killer monster on the loose.

Five mismatched teenagers are stuck with each other for the day when they are forced to spend Saturday at school on detention. Gradually, though, unlikely friendships form. John Hughes' seminal high school comedy set the template for a number of 1980s teen movies, while Simple Minds scored a huge hit with their theme song, 'Don't You Forget About Me'.