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Calcium Entry Blockers (CEBs) are a new class of drugs which have
been pushing back the frontiers of science and medicine for almost
two decades. This report reviews some of the wealth of chemical,
biological and clinical data describing the discovery and
development of these compounds. The scientific importance,
therapeutic benefit and marketing potential of these compounds have
caused an explosion of scientific literature describing their
effects in many preclinical and clinical settings. The definitional
characteristics of these compounds suggest a certain predictability
of their biological profile but their therapeutic usefulness varies
widely dependent upon their physical properties, net hemodynamic
effects, duration of action and incidence of side effects. CEBs
appear uniquely suited to the treatment of the underlying
complexity of cardiovascular disease. The CEBs of the future may
live up to the expectations of pathophysiologically based
therapeutics and allow the heart and blood vessels to outlive the
cells which they support. The development of CEBs is an evolving
story of epic proportions and represents the cooperative efforts of
individuals in all areas of science.
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