Biologist Margo Green (Penelope Ann Miller) teams up with police Lieutenant D'Agosta (Tom Sizemore) to investigate a series of grisly murders at her place of work - the Natural History museum. Can there be a link with the recently-arrived crates belonging to a missing anthropologist from Brazil? All that is found in the crates are some leaves covered with a strange fungus, which when analysed proves capable of mutating whoever eats it. When a guard is killed and a headless body interrupts the museum's exhibition gala, Margo and D'Agosta discover that there is an ancient killer monster on the loose.

Biologist Margo Green (Penelope Ann Miller) teams up with police Lieutenant D'Agosta (Tom Sizemore) to investigate a series of grisly murders at her place of work - the Natural History museum. Can there be a link with the recently-arrived crates belonging to a missing anthropologist from Brazil? All that is found in the crates are some leaves covered with a strange fungus, which when analysed proves capable of mutating whoever eats it. When a guard is killed and a headless body interrupts the museum's exhibition gala, Margo and D'Agosta discover that there is an ancient killer monster on the loose.