In recent years a number of scholars have analyzed the management of BSE, also known as 'mad cow disease'. The BSE crisis is regarded by many as an example of the failure of officials and politicians to handle risk situations. Yet, BSE is also characterized by a unique trait, that is, the infectious agent that causes it. Thus far, no one has paid attention to the fact that BSE and other transmissible spongiform encephalopathy's (TSEs) are allegedly caused by a novel agent - a prion - distinct from all other known infectious agents such as bacteria and viruses. The prion hypothesis was introduced by the American scientist Stanley Prusiner in 1982. It immediately created a controversy among scientists and is still rejected by some. Yet, despite this lack of consensus in the scientific community, Prusiner was awarded the Nobel Prize for medicine in 1997. This book analyzes the introduction, reception, development and consequences of the prion hypothesis. It shows that BSE is a unique case not only in virtue of its political mismanagement but also because its infectious agent has created a form of revolution in biology.

Perhaps better than any other city, Manchester illustrates the historical relationship between the growth of science and the growth of industry - a relationship which is topical now, as it has been for two centuries. This introduction provides a sketch map and some references for those who would like to explore this local and regional history.

This book charts the history of the worldwide introduction of an operative treatment method for broken bones, osteosynthesis, by a Swiss-based association, called AO. The success of the close cooperation between the AO's surgeons, scientists and manufacturers in establishing a complicated and risky technique as a standard treatment sheds light on the mechanisms of medical innovation at the crossroads of surgery, science and industry and the nature of modern medicine in general.

This is a discussion of the historical development of science, technology and medicine in Western Europe and North America from the Renaissance to the present. By linking its development to the wider context of human society, the constant changing process of human perception, comprehension and manipulation of the world is revealed. Four principal ways of knowing are identified within particular periods: natural history in the 18th century; analysis following the French Revolution; experiment in the epoch of modernism; and the current presence of technoscience. John Pickstone balances the historical exposition of natural magic and natural theology with a philosophical interpretation of the Scientific Revolution and reflective comments on Foucault and Collingwood.

This book charts the history of the worldwide introduction of an operative treatment method for broken bones, osteosynthesis, by a Swiss-based association, called AO. The success of the close cooperation between the AO's surgeons, scientists and manufacturers in establishing a complicated and risky technique as a standard treatment sheds light on the mechanisms of medical innovation at the crossroads of surgery, science and industry and the nature of modern medicine in general.

This book in the highly respected Cambridge History of Science series is devoted to the history of the life and earth sciences since 1800. It provides comprehensive and authoritative surveys of historical thinking on major developments in these areas of science, on the social and cultural milieus in which the knowledge was generated, and on the wider impact of the major theoretical and practical innovations. The articles were written by acknowledged experts who provide concise accounts of the latest historical thinking coupled with guides to the most important recent literature. In addition to histories of traditional sciences, the book covers the emergence of newer disciplines such as genetics, biochemistry, and geophysics. The interaction of scientific techniques with their practical applications in areas such as medicine is a major focus of the book, as is its coverage of controversial areas such as science and religion and environmentalism.