The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.

"Human Nature: Fact and Fiction" brings together a collection of inspiring, thought-provoking and original perspectives on human nature by ten leading writers, scientists and academics. What do we mean by 'human nature'? Is there a genetically determined core of humanity that unites us all as members of a single species? Or is the thing we call human nature a social construct? And how do we explain the mystery of human creativity? Do great writers have an intuitive grasp of what makes human beings tick, or are they merely the mouthpiece of contemporary culture? It has been claimed that 'the greatest enterprise of the mind has always been and always will be the attempted linkage of the sciences and humanities' (Edward O. Wilson). This groundbreaking book marks the beginning of a new dialogue between the two. Rather than focusing on the division between them, it shows that the sciences and humanities have much to learn from each other. Points of disagreement remain. Yet there is in this volume a genuine attempt to bridge the gulf that has traditionally separated the sciences and humanities and to reach a better understanding of what it means to be human. "Human Nature: Fact and Fiction" is a major new contribution to the debate on human nature, set to be required reading for anyone with a background in either the arts or the sciences who is interested in understanding what defines us as human beings - in what we are, and why.

How did life start? How did something capable of replicating itself emerge from the primordial soup? How did it defy the odds? And how did it carry on seeking out those very mutations that enable survival? Life is an extraordinary phenomenon who existence requires an extraordinary explanation.

Living organisms are controlled by a single molecule – DNA. Yet the study of physics tells us that the behaviour of single molecules is controlled not by classical laws but by the strange laws of quantum mechanics. The implications of this for biology have never been fully explored. Until now. In this brilliant debut, Johnjoe McFadden puts forward a theory of quantum evolution. He shows how quantum mechanics gives living organisms the ability to initiate specific actions including new mutations. Indeed, such an ability may be life's most fundamental attribute. This simple but staggering theory has radical implications. Evolution may not be random at all, as evolutionary theorists have taught recently: rather it may be directed – cells may, in certain circumstances, be able to choose to mutate particular genes that provide an advantage in the environment in which the cell finds itself.

This property of living organisms to direct their actions has startling implications. It must be at the root of both consciousness and free will: 'Quantum Evolution' provides a new understanding of the origin of life and the meaning of death. Life, this brilliant book argues, is a quantum phenomenon. 'Quantum Evolution' provides a new biology for the new millennium.

'The most sheerly enjoyable history of science of recent years' The Spectator 'This is one of the best science books I have read in a decade' Paul Davies Life is Simple tells the remarkable story of how a thirteenth century monk's search for simplicity led to the emergence of the modern world. We begin in the turbulent times of the medieval friar, William of Occam, who first articulated the principle that the best answer to any problem is the simplest. This theory, known as Occam's razor, cut through the thickets of medieval metaphysics to clear a path for modern science. We follow the razor in the hands of the giants of science, from Copernicus, to Kepler, Galileo, Newton, Darwin, Einstein, Rubin and Higgs. Its success suggests that we live in the simplest possible habitable universe and supports the revolutionary theory that our cosmos has evolved. By highlighting the very human passion, curiosity, mistakes and struggles of those who were inspired by Occam's razor to create the modern world, Johnjoe McFadden provides new insight into what science is really about. And that the principle of simplicity is as relevant today as ever.

Life is the most extraordinary phenomenon in the known universe; but how does it work? Even in this age of cloning and synthetic biology, the remarkable truth remains: nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we missing a vital ingredient in its creation? Like Richard Dawkins' The Selfish Gene, which provided a new perspective on evolution, Life on the Edge alters our understanding of life's dynamics as Jim Al-Khalili and Johnjoe Macfadden reveal the hitherto missing ingredient to be quantum mechanics. Drawing on recent ground-breaking experiments around the world, they show how photosynthesis relies on subatomic particles existing in many places at once, while inside enzymes, those workhorses of life that make every molecule within our cells, particles vanish from one point in space and instantly materialize in another. Each chapter in Life on the Edge opens with an engaging example that illustrates one of life's puzzles - How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes manage to copy themselves with such precision? - and then reveals how quantum mechanics delivers its answer. Guiding the reader through the maze of rapidly unfolding discovery, Al-Khalili and McFadden communicate vividly the excitement of this explosive new field of quantum biology, with its potentially revolutionary applications, and also offer insights into the biggest puzzle of all: what is life?

'The most sheerly enjoyable history of science of recent years' The Spectator 'This is one of the best science books I have read in a decade' Paul Davies Life is Simple tells the remarkable story of how a thirteenth century monk's search for simplicity led to the emergence of the modern world. We begin in the turbulent times of the medieval friar, William of Occam, who first articulated the principle that the best answer to any problem is the simplest. This theory, known as Occam's razor, cut through the thickets of medieval metaphysics to clear a path for modern science. We follow the razor in the hands of the giants of science, from Copernicus, to Kepler, Galileo, Newton, Darwin, Einstein, Rubin and Higgs. Its success suggests that we live in the simplest possible habitable universe and supports the revolutionary theory that our cosmos has evolved. By highlighting the very human passion, curiosity, mistakes and struggles of those who were inspired by Occam's razor to create the modern world, Johnjoe McFadden provides new insight into what science is really about. And that the principle of simplicity is as relevant today as ever.

The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.

'The most sheerly enjoyable history of science of recent years' The Spectator 'This is one of the best science books I have read in a decade' Paul Davies Life is Simple tells the remarkable story of how a thirteenth century monk's search for simplicity led to the emergence of the modern world. We begin in the turbulent times of the medieval friar, William of Occam, who first articulated the principle that the best answer to any problem is the simplest. This theory, known as Occam's razor, cut through the thickets of medieval metaphysics to clear a path for modern science. We follow the razor in the hands of the giants of science, from Copernicus, to Kepler, Galileo, Newton, Darwin, Einstein, Rubin and Higgs. Its success suggests that we live in the simplest possible habitable universe and supports the revolutionary theory that our cosmos has evolved. By highlighting the very human passion, curiosity, mistakes and struggles of those who were inspired by Occam's razor to create the modern world, Johnjoe McFadden provides new insight into what science is really about. And that the principle of simplicity is as relevant today as ever.

"Human Nature: Fact and Fiction" brings together a collection of inspiring, thought-provoking and original perspectives on human nature by ten leading writers, scientists and academics. What do we mean by 'human nature'? Is there a genetically determined core of humanity that unites us all as members of a single species? Or is the thing we call human nature a social construct? And how do we explain the mystery of human creativity? Do great writers have an intuitive grasp of what makes human beings tick, or are they merely the mouthpiece of contemporary culture? It has been claimed that 'the greatest enterprise of the mind has always been and always will be the attempted linkage of the sciences and humanities' (Edward O. Wilson). This groundbreaking book marks the beginning of a new dialogue between the two. Rather than focusing on the division between them, it shows that the sciences and humanities have much to learn from each other. Points of disagreement remain. Yet there is in this volume a genuine attempt to bridge the gulf that has traditionally separated the sciences and humanities and to reach a better understanding of what it means to be human. "Human Nature: Fact and Fiction" is a major new contribution to the debate on human nature, set to be required reading for anyone with a background in either the arts or the sciences who is interested in understanding what defines us as human beings - in what we are, and why.