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This book has been written in response to the many physicians and
scien tists working on the development of biological approaches to
providing therapies for many orthopaedic disorders as well as to
improving the healing of many tissues of the musculoskeletal
system. The first goal of this book is to make the language
compatible between the bench scientist and the clinician working in
orthopaedic and sports medicine in order to cover specific areas of
the orthopaedic discipline where the treatment can be improved
and/or changed by the advancements in molecular medicine.
Advancements in molecular biology, which encompass the study of the
genetic basis of disease, have produced new diagnostic methods and
drug therapies for genetic diseases and acquired disorders. The
growth in the understanding of human genetics has also led to the
initiation of many human gene therapy experiments. Although many
approved therapeutic clinical trials using this new technology have
been performed in the last ten years, the first clinical trial
using this technology in the area of orthopaedics was performed at
the University of Pittsburgh."
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