People diagnosed with different health conditions often experience emotional disorders or anxiety and depressive symptoms at some point. The Unified Protocol (UP) is a transdiagnostic treatment protocol that aims to improve emotion regulation difficulties contributing to emotional disorder symptoms (including comorbidity) and other affective components related to the physical disease. In Applications of the Unified Protocol in Health Conditions, the leading UP experts provide valuable insights to clinicians into how the UP—a single, scalable, cognitive behavioral therapy protocol—can be modified in relatively minor ways to address the emotional difficulties that often accompany these health conditions in different treatment settings. This book provides clinicians with a "how to" guide for using the UP to treat a range of commonly encountered mental health issues that are present in health conditions in adults. Each chapter focuses on a specific health condition and provides a rationale for using the UP in treatment, a description of how to apply core UP treatment modules, and guidance on making adaptions to the protocol. Application of the protocol is illustrated through case studies that include case conceptualization, treatment planning, and assessment of clinical outcomes.