This book constitutes the thoroughly refereed post-conference proceedings of the 10th International Conference on Quantum Interaction, QI 2016, held in San Francisco, CA, USA, in July 2016. The 21 papers presented in this book were carefully reviewed and selected from 39 submissions. The papers address topics such as: Fundamentals; Quantum Cognition; Language and Applications; Contextuality and Foundations of Probability; and Quantum-Like Measurements.