This book is a comprehensive overview of the main current concepts in brain cognitive activities at the global, collective (or network) level, with a focus on transitions between normal neurophysiology and brain pathological states. It provides a unique approach of linking molecular and cellular aspects of normal and pathological brain functioning with their corresponding network, collective and dynamical manifestations that are subsequently extended to behavioral manifestations of healthy and diseased brains. This book introduces a high-level perspective, searching for simplification amongst the structural and functional complexity of nervous systems by consideration of the distributed interactions that underlie the collective behavior of the system. The authors hope that this approach could promote a global comprehensive understanding of high-level laws behind the elementary biological processes in the neuroscientific community, while, perhaps, introducing elements of biological complexities to the mathematical/computational readership. The title of the book refers to the main point of the monograph: that there is a smooth continuum between distinct brain activities resulting in different behaviors, and that, due to the plastic nature of the brain, the behavior can also alter the brain function, thus rendering artificial the boundaries between the brain and its behavior.

Increasing interest in the study of coordinated activity of brain cell ensembles reflects the current conceptualization of brain information processing and cognition. It is thought that cognitive processes involve not only serial stages of sensory signal processing, but also massive parallel information processing circuitries, and therefore it is the coordinated activity of neuronal networks of brains that give rise to cognition and consciousness in general. While the concepts and techniques to measure synchronization are relatively well characterized and developed in the mathematics and physics community, the measurement of coordinated activity derived from brain signals is not a trivial task, and is currently a subject of debate. Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behavior addresses conceptual and methodological limitations, as well as advantages, in the assessment of cellular coordinated activity from neurophysiological recordings. The book offers a broad overview of the field for investigators working in a variety of disciplines (neuroscience, biophysics, mathematics, physics, neurology, neurosurgery, psychology, biomedical engineering, computer science/computational biology), and introduces future trends for understanding brain activity and its relation to cognition and pathologies. This work will be valuable to professional investigators and clinicians, graduate and post-graduate students in related fields of neuroscience and biophysics, and to anyone interested in signal analysis techniques for studying brain function.

"Perez Velazquez has written a little gem that I advise reading to anyone persuing a scientific career, as well as for the general public interested in the sociological aspects of science. It alerts the reader about the rise of a new type of scientist, buried in bureaucracy and financial issues. In contrast to past generations, this "new scientist" is sadly left with minimal time to dedicate to creative work. It studies the consequences of this state of affairs, the problems associated with peer reviewing, the dilemma of funding innovative research, the nature of corporate academic culture and the trivialization of scientific achievement by grant agencies and universities. It also provides possible solutions for these problems. All this is magnificently exemplified and documented, including personal experiences from the author and a touch of humor illustrated in the accompanying cartoons. Despite the humor, it is a serious piece of work that would also be useful for the conscientious academic worried about the difficulties of the current research scene." Marina Frantseva, MD, PhD Jose Luis Perez Velazquez is a Spanish biochemist/biophysicist. He has a degree in Biochemistry and a PhD in Molecular Physiology & Biophysics. His research activities are mainly in the fields of the brain-behaviour relation at a high level of description, seeking principles of biological organisation. He worked as a senior scientist at the Hospital for Sick Children in Toronto and was Professor at the University of Toronto, where he taught a graduate course on consciousness and self-awareness, which derived in part from his book The Brain-Behaviour Continuum (World Scientific). He also edited the book Coordinated Activity in the Brain (Springer), and edited special issues for The Journal of Biological Physics, Frontiers in Integrative Neuroscience and Frontiers in Computational Neuroscience. Currently he is a Research Scholar at the Ronin Institute, where he continues to investigate a possible global principle, a scheme that combines theoretical studies and experimental observations, aimed at conceptualizing how consciousness arises from the organization of matter.

Increasing interest in the study of coordinated activity of brain cell ensembles reflects the current conceptualization of brain information processing and cognition. It is thought that cognitive processes involve not only serial stages of sensory signal processing, but also massive parallel information processing circuitries, and therefore it is the coordinated activity of neuronal networks of brains that give rise to cognition and consciousness in general. While the concepts and techniques to measure synchronization are relatively well characterized and developed in the mathematics and physics community, the measurement of coordinated activity derived from brain signals is not a trivial task, and is currently a subject of debate. Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behavior addresses conceptual and methodological limitations, as well as advantages, in the assessment of cellular coordinated activity from neurophysiological recordings. The book offers a broad overview of the field for investigators working in a variety of disciplines (neuroscience, biophysics, mathematics, physics, neurology, neurosurgery, psychology, biomedical engineering, computer science/computational biology), and introduces future trends for understanding brain activity and its relation to cognition and pathologies. This work will be valuable to professional investigators and clinicians, graduate and post-graduate students in related fields of neuroscience and biophysics, and to anyone interested in signal analysis techniques for studying brain function.

About the Editors:

J. L. Perez Velazquez was born in Zaragoza, Spain, and received the degree of 'Licenciado' in Chemistry (Biochemistry, universities of Zaragoza and Complutense of Madrid), and a PhD degree in 1992 from the Department of Molecular Physiology and Biophysics at Baylor College of Medicine (Houston), homologated to Doctorate in Chemistry by the Spanish Ministry of Culture in 1997. He is an Associate Scientist in the Neuroscience and Mental Health Programme and the Brain and Behaviour Centre at the Hospital For Sick Children in Toronto, and an Associate Professor at the University of Toronto.

Richard Wennberg was born in Vancouver, Canada. He obtained his medical degree from the University of British Columbia in 1990 and completed a neurology residency at McGill University in 1994, followed by a fellowship in electroencephalography at the Montreal Neurological Institute. He is Director of the clinical neurophysiology laboratory at the University Health Network, Toronto Western Hospital; Associate professor of Medicine at the University of Toronto; Chair of the Royal College of Physicians and Surgeons of Canada examination board in neurology, and President of the Canadian League Against Epilepsy.

"Perez Velazquez has written a little gem that I advise reading to anyone persuing a scientific career, as well as for the general public interested in the sociological aspects of science. It alerts the reader about the rise of a new type of scientist, buried in bureaucracy and financial issues. In contrast to past generations, this "new scientist" is sadly left with minimal time to dedicate to creative work. It studies the consequences of this state of affairs, the problems associated with peer reviewing, the dilemma of funding innovative research, the nature of corporate academic culture and the trivialization of scientific achievement by grant agencies and universities. It also provides possible solutions for these problems. All this is magnificently exemplified and documented, including personal experiences from the author and a touch of humor illustrated in the accompanying cartoons. Despite the humor, it is a serious piece of work that would also be useful for the conscientious academic worried about the difficulties of the current research scene." Marina Frantseva, MD, PhD Jose Luis Perez Velazquez is a Spanish biochemist/biophysicist. He has a degree in Biochemistry and a PhD in Molecular Physiology & Biophysics. His research activities are mainly in the fields of the brain-behaviour relation at a high level of description, seeking principles of biological organisation. He worked as a senior scientist at the Hospital for Sick Children in Toronto and was Professor at the University of Toronto, where he taught a graduate course on consciousness and self-awareness, which derived in part from his book The Brain-Behaviour Continuum (World Scientific). He also edited the book Coordinated Activity in the Brain (Springer), and edited special issues for The Journal of Biological Physics, Frontiers in Integrative Neuroscience and Frontiers in Computational Neuroscience. Currently he is a Research Scholar at the Ronin Institute, where he continues to investigate a possible global principle, a scheme that combines theoretical studies and experimental observations, aimed at conceptualizing how consciousness arises from the organization of matter.

Many people spend considerable time seeking a sense of purpose in life and, concomitant with that, a sense of personal identity. This book demystifies this search, revealing why this search is a fallacy. The purpose is to inform readers about results in neuroscience and biophysics that may guide us to some liberation needed in the current age of great complexity in life with a diverse burden of chores; a deliverance from some afflictions that prevent individuals from achieving the true purpose of our lives. Among these afflictions we find two primordial concerns: the belief and subsequent attachment to a self, and the conviction that life must have a deep purpose in which we are major players. While this is a scientific text, it can easily be read by a lay audience, written with minimal technical jargon and with references to scientific papers enough to satisfy the curious. We have tried to extract the essence of scientific observations such that we can glimpse at those aforementioned concerns about the self and life, observations which help us comprehend what we are and what we become, the being and becoming of our own selves and natural phenomena around us. Jose Luis Perez Velazquez received a PhD in Molecular Physiology & Biophysics. His research seeks principles of biological organisation. He worked at the Hospital for Sick Children in Toronto and was Professor at the University of Toronto. Currently he is a Research Scholar at the Ronin Institute and lives in the natural paradise of Asturias, in Northern Spain. Vera Nenadovic is a nurse practitioner, neuroscientist and entrepreneur. She has 30 years of experience in healthcare from First Nations communities to intensive care units. Her research focuses on predicting brain injury outcomes. She is a clinician and researcher at Holland Bloorview Kids Rehab Hospital. Her startup company BrainsView is commercializing software that analyzes brainwaves to monitor brain function and recovery after head injury. She is married and lives in Toronto, with her husband and Rottweiler.