This book constitutes the refereed proceedings of the 21st International Conference on Artificial Intelligence in Medicine, AIME 2023, held in Portoroz, Slovenia, in June12–15, 2023. The 23 full papers and 21 short papers presented together with 3 demonstration papers were selected from 108 submissions. The papers are grouped in topical sections on: machine learning and deep learning; explainability and transfer learning; natural language processing; image analysis and signal analysis; data analysis and statistical models; knowledge representation and decision support.

This book constitutes revised selected papers from the AIME 2019 workshops KR4HC/ProHealth 2019, the Workshop on Knowledge Representation for Health Care and Process-Oriented Information Systems in Health Care, and TEAAM 2019, the Workshop on Transparent, Explainable and Affective AI in Medical Systems. The volume contains 5 full papers from KR4HC/ProHealth, which were selected out of 13 submissions. For TEAAM 8 papers out of 10 submissions were accepted for publication.