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This volume reports the proceedings of a NATO Advanced Workshop
held in Castelvecchio Pas coli, Italy, from August 28 - September
1, 1989. An important inspiration for this Workshop came from our
studies in Helsinki and Denmark, which have found that exposure to
an influenza epidemic during the second trimester of fetal
development increases the risk of adult schizophrenia. This finding
has stimulated an important new hypothesis in the study of the
etiology of schizophrenia. It has suggested the possiblity that
disturbances of brain development during gestation may contribute
to the risk of adult schizophrenia. We determined that it would be
of value to bring together schizophrenia researchers and those
doing basic studies of the development of the brain. Both groups of
researchers were encouraged to communicate at a level that would
help other scientists to integrate their knowledge and techniques
into their own discipline. For this reason, perhaps, the papers of
this volume are remarkably clear and not difficult to understand.
The first four chapters describe the neurochemical and structural
aspects of brain development. The chapter by Dziegielewska and
Saunders discusses transport mechanisms and the properties of
endogenous and exogenous substances that control the internal
environment of the developing brain. In the second chapter,
Nowakowski reports on his studies of the develop ment of the
hippocampus in mice genetically inbred to exhibit disruptions of
neural migration.
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