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In Gene Therapy Protocols, Volumes 1 & 2, internationally
recognized investigators describe cutting-edge laboratory
techniques for the study of Production and In Vivo Applications of
Gene Transfer Vectors (Volume 1) and Design and Characterization of
Gene Transfer Vectors (Volume 2). The field of gene therapy has
undergone remarkable advances, promising to impact human healthcare
significantly in the twenty-first century. Todaya (TM)s
technologies can deliver genetic material safely and effectively to
cells to slow or halt the progression of disease, and to help
repair or regenerate damaged or lost tissues. In this second volume
of Gene Therapy Protocols: Design and Characterization of Gene
Transfer Vectors, readers will find a comprehensive resource of
current and emerging methods for the processing and
characterization of viral and non-viral gene transfer vectors, as
well as promising approaches to design vectors for efficient,
targeted and regulated gene delivery and expression. This second
volume of the new and completely revised third edition of Gene
Therapy Protocols will prove a necessary tool for graduate students
and postdoctoral fellows and invaluable to basic and clinical
researchers in both industry and academia.
In this book internationally recognized investigators describe
cutting-edge laboratory techniques for the study of Production and
In Vivo Applications of Gene Transfer Vectors and Design and
Characterization of Gene Transfer Vectors. Readers will find a
comprehensive resource of current and emerging methods for the
production of viral and non-viral gene transfer vectors, as well as
detailed protocols for applications in stem cell biology, cancer
research and infectious disease.
In Gene Therapy Protocols, Volumes 1 and 2, internationally
recognized investigators describe cutting-edge laboratory
techniques for the study of Production and In Vivo Applications of
Gene Transfer Vectors (Volume 1) and Design and Characterization of
Gene Transfer Vectors (Volume 2). In this second volume, readers
will find a comprehensive resource of current and emerging methods
for the processing and characterization of viral and non-viral gene
transfer vectors.
Anxiety is the most prevalent psychiatric problem of our time.
Decades of research have gone into probing its mysteries and
developing treatments. But what if we've been thinking about fear
and anxiety in the wrong way for all these years? This is the
groundbreaking premise behind a wave of new research, led by the
lab of renowned neuroscientist Joseph LeDoux. He believes that fear
and anxiety are not innate states, simply waiting to be unleashed
in the brain. Rather they are assembled experiences, and that has
huge implications for patients. By mapping brain circuits, LeDoux
explains the origins of anxiety disorders and reveals discoveries
that can restore sufferers to normality. As impressive as it is
timely, Anxious is a comprehensive survey of cutting-edge research
revolutionising the way we treat our most pressing mental health
issue.
"A rigorous, in-depth guide to the history, philosophy, and
scientific exploration of this widespread emotional state . . .
[LeDoux] offers a magisterial review of the role of mind and brain
in the generation of unconscious defense responses and consciously
expressed anxiety. . . . [His] charming personal asides give an
impression of having a conversation with a world expert." -Nature A
comprehensive and accessible exploration of anxiety, from a leading
neuroscientist and the author of Synaptic Self Collectively,
anxiety disorders are our most prevalent psychiatric problem,
affecting about forty million adults in the United States. In
Anxious, Joseph LeDoux, whose NYU lab has been at the forefront of
research efforts to understand and treat fear and anxiety, explains
the range of these disorders, their origins, and discoveries that
can restore sufferers to normalcy. LeDoux's groundbreaking premise
is that we've been thinking about fear and anxiety in the wrong
way. These are not innate states waiting to be unleashed from the
brain, but experiences that we assemble cognitively. Treatment of
these problems must address both their conscious manifestations and
underlying non-conscious processes. While knowledge about how the
brain works will help us discover new drugs, LeDoux argues that the
greatest breakthroughs may come from using brain research to help
reshape psychotherapy. A major work on one of our most pressing
mental health issues, Anxious explains the science behind fear and
anxiety disorders. Praise for Anxious: "[Anxious] helps to explain
and prevent the kinds of debilitating anxieties all of us face in
this increasingly stressful world." -Daniel J. Levitin, author of
The Organized Mind and This Is Your Brain on Music "A careful tour
through the current neuroscience of fear and anxiety . . .
[Anxious] will reward the informed reader." -The Wall Street
Journal "An extraordinarily ambitious, provocative, challenging,
and important book. Drawing on the latest research in neuroscience
(including work in his own laboratory), LeDoux provides
explanations of the origins, nature, and impact of fear and anxiety
disorders." -Psychology Today
The science behind David Goleman's Emotional Intelligence The
Emotional Brain provides a cutting-edge scientific background to
such books as Daniel Goleman's Emotional Intelligence, showing that
while cognitive studies have tended to ignore the emotions, we are
increasingly understanding how crucial they are to our evolutionary
survival, as shortcuts to cut through conscious reasoning when
speed and rules-of-thumb are more important and effective than
logic. Much of our emotional life is lived unconsciously, and is
far richer than simply our conscious feelings - for example, our
conscious mind will already be reacting to situations of danger
some time before we begin to be afraid. Not only does LeDoux
present a fascinating insight into how our emotions function
normally, but also provides a new understanding of emotional
disorders.
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