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Cytokines and Inflammation (Hardcover, New)
Edward S. Kimball; Series edited by Patrick J. Kelly; Contributions by Heinz Baumann, Jack Gauldie, Joseph Lorenzo, …
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R8,799
Discovery Miles 87 990
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Ships in 12 - 17 working days
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This important new book focuses on the involvement of cytokines in
specific areas of inflammatory diseases, such as granulomatous
responses, lung disease, hepatic dysfunction and the acute phase,
arthritis and accompanying bone remodeling, neurogenic
inflammation, and shock. The roles of GM-CSF, IL-6, IL-2, TGFb EGF,
and LIF are discussed, as well as the medical treatments that
affect cytokine activity. The results of approaches important to
the biotechnology and pharmaceutical industries, such as the search
for endogenous biological response modifiers that control cytokine
function or production, attempts to synthesize heterocyclic
compounds in the organic chemistry lab, and research regarding
second messenger pathways involved in IL-1 and TNF production are
examined. This book will provide anyone in cytokine research,
especially clinical investigators, pharmaceutical industry
researchers, and academic research scientists, with important
information on how cytokine research might be used.
Osteoimmunology: Interactions of the Immune and Skeletal Systems,
Second Edition, explores the advancements that have been made in
the field during the last 40 years, including valuable information
on our understanding of the interactions between hematopoietic,
immune, and bone cells, now known as the field of osteoimmunology.
This comprehensive work offers the most extensive summaries of
research trends in the field and their translation into new
therapeutics. Early chapters deal with the development of
osteoblasts, osteoclasts, hematopoietic stem cells, T and
B-lymphocytes, and communications between these cellular elements,
while later sections contain discussions of the signaling pathways
by which RANKL influences osteoclast development and function.
Subsequent chapters explore the effects that estrogen has on bone
and the immune system, the development of pathologic conditions,
and the growing research around osteoporosis, Paget's disease, the
genetics of bone disease, and bone cancer metastasis.
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