This book describes the growing body of information on the epidemiology, clinical manifestations, transmission, pathogenesis, diagnosis, and treatment of Kingella kingae infections in young children. In addition, it covers experimental methods that have been developed to study the microbiology, genetics, and virulence factors of K. kingae, information that provides the foundation for new approaches to treatment and prevention of K. kingae disease. With this content in mind, excerpts from the book will be of relevance for clinicians who care for pediatric patients, for clinical microbiologists who are involved in detecting organisms in clinical specimens, and for scientists who are studying K. kingae in an effort to develop novel targets for antimicrobial therapy and new approaches to prevention. First isolated in the 1960s by Elizabeth O. King, a bacteriologist at the CDC, Kingella kingae was largely ignored over the next two decades as a human pathogen because of its uncommon recovery from patients with disease. However, in recent years K. kingae has been increasingly recognized as a clinically important pathogen in young children, and is currently recognized as the leading cause of osteoarticular infections in young children in a growing number of countries. Research into this organism has grown tremendously over the past 15 years, resulting in a better appreciation of the importance of K. kingae in pediatric patients and of the molecular mechanisms of disease.

Welcome to the 21st Edition of Nelson Textbook of Pediatrics - the reference of choice among pediatricians, pediatric residents, and others involved in the care of young patients. This fully revised edition continues to provide the breadth and depth of knowledge you expect from Nelson, while also keeping you up to date with new advances in the science and art of pediatric practice. Authoritative and reader-friendly, it delivers the information you need in a concise, easy-to-use format for everyday reference and study. From rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today, this comprehensive 2-volume reference keeps you on the cutting edge of the very best in pediatric care. Includes more than 70 new chapters, including Postural Orthostatic Tachycardia Syndrome (POTS), Rare and Undiagnosed Diseases, Approach to Mitochondrial Disorders, Electronic Nicotine Delivery Systems, Zika, update on Ebola, Epigenetics, Autoimmune Encephalitis, Global Health, Racism, Media Violence, Strategies for Health Behavior Change, Positive Parenting, and many more. Features hundreds of new figures and tables throughout for visual clarity and quick reference. Offers new and expanded information on CRISPR gene editing; LGBT health care; gun violence; vaccinations; immune treatment with CAR-T cells; new technology in imaging and genomics; new protocols in cancer, genetics, immunology, and pulmonary medicine; and much more. Provides fresh perspectives from four new associate editors: Nathan J. Blum of The Children's Hospital of Philadelphia; Karen Wilson of Mt. Sinai School of Medicine in New York; Samir S. Shah of Cincinnati Children's Hospital Medical Center; and Robert C. Tasker of Boston Children's Hospital. Provides regular updates online, written exclusively for Nelson. Remains your indispensable source for definitive, evidence-based answers on every aspect of pediatric care. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Review and retain the information you need for success on the boards with Nelson Pediatrics Board Review: Certification and Recertification. This highly practical review tool follows the American Board of Pediatrics (ABP) general pediatrics content outline, with topics weighted to correlate with the exam. Must-know information is presented in a way that's easy to study and remember, and is backed by the Nelson family of references that you know and trust for current, authoritative information in your field. Equips residents and physicians with an efficient, comprehensive system for study, designed specifically to help you perform at your best on the board exam. Presents information in a bulleted, high-yield format, with topics matching ABP content guidelines. Provides a real-world balance of necessary fundamental information and cutting-edge advances - all carefully written and reviewed by editors and contributors from the world renowned Children's Hospital of Philadelphia (CHOP). Features over 600 board-style questions with full, discursive answers online. Includes reader-friendly features that promote testing success: tables that show differences between diagnoses, genetic disorders grouped by key features in phenotypic presentation rather than in alphabetical order, and more - all designed to help you recall key information when taking exams. Provides online links to the Nelson Textbook of Pediatrics that offer a complete presentation of the content, including evidence-based treatment and management. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.