Design of the aseptic processing system and thermal processing Thermal process equipment and technology for heating and cooling Flow and residence time distribution (RTD) for homogenous and heterogenous fluids Thermal process and optimization of aseptic processing containing solid particulates Aseptic filling and packaging equipment for retail products and food service Design of facility, infrastructure and utilities Cleaning and sanitization for aseptic processing and packaging operations Microbiology of aseptically processed and packaged products Risk-based analyses and methodologies Establishment of "validated state" for aseptic processing and packaging systems Quality and food safety management systems for aseptic and ESL manufacturing Computational and numerical models and simulations for aseptic processing Also, there are 7 new appendices on original patents, examples of typical thermal process calculations, and particulate studies - single particle and multiple-type particles, and FDA filing.