This proceedings volume presents a diverse collection of high-quality, state-of-the-art research and survey articles written by top experts in low-dimensional topology and its applications. The focal topics include the wide range of historical and contemporary invariants of knots and links and related topics such as three- and four-dimensional manifolds, braids, virtual knot theory, quantum invariants, braids, skein modules and knot algebras, link homology, quandles and their homology; hyperbolic knots and geometric structures of three-dimensional manifolds; the mechanism of topological surgery in physical processes, knots in Nature in the sense of physical knots with applications to polymers, DNA enzyme mechanisms, and protein structure and function. The contents is based on contributions presented at the International Conference on Knots, Low-Dimensional Topology and Applications - Knots in Hellas 2016, which was held at the International Olympic Academy in Greece in July 2016. The goal of the international conference was to promote the exchange of methods and ideas across disciplines and generations, from graduate students to senior researchers, and to explore fundamental research problems in the broad fields of knot theory and low-dimensional topology. This book will benefit all researchers who wish to take their research in new directions, to learn about new tools and methods, and to discover relevant and recent literature for future study.

This volume consists primarily of survey papers that evolved from the lectures given in the school portion of the meeting and selected papers from the conference.Knot theory is a very special topological subject: the classification of embeddings of a circle or collection of circles into three-dimensional space. This is a classical topological problem and a special case of the general placement problem: Understanding the embeddings of a space X in another space Y. There have been exciting new developments in the area of knot theory and 3-manifold topology in the last 25 years. From the Jones, Homflypt and Kauffman polynomials, quantum invariants of 3-manifolds, through, Vassiliev invariants, topological quantum field theories, to relations with gauge theory type invariants in 4-dimensional topology.More recently, Khovanov introduced link homology as a generalization of the Jones polynomial to homology of chain complexes and Ozsvath and Szabo developed Heegaard-Floer homology, that lifts the Alexander polynomial. These two significantly different theories are closely related and the dependencies are the object of intensive study. These ideas mark the beginning of a new era in knot theory that includes relationships with four-dimensional problems and the creation of new forms of algebraic topology relevant to knot theory. The theory of skein modules is an older development also having its roots in Jones discovery. Another significant and related development is the theory of virtual knots originated independently by Kauffman and by Goussarov Polyak and Viro in the '90s. All these topics and their relationships are the subject of the survey papers in this book.It is a remarkable fact that knot theory, while very special in its problematic form, involves ideas and techniques that involve and inform much of mathematics and theoretical physics. The subject has significant applications and relations with biology, physics, combinatorics, algebra and the theory of computation. The summer school on which this book is based contained excellent lectures on the many aspects of applications of knot theory. This book gives an in-depth survey of the state of the art of present day knot theory and its applications.

This proceedings volume presents a diverse collection of high-quality, state-of-the-art research and survey articles written by top experts in low-dimensional topology and its applications. The focal topics include the wide range of historical and contemporary invariants of knots and links and related topics such as three- and four-dimensional manifolds, braids, virtual knot theory, quantum invariants, braids, skein modules and knot algebras, link homology, quandles and their homology; hyperbolic knots and geometric structures of three-dimensional manifolds; the mechanism of topological surgery in physical processes, knots in Nature in the sense of physical knots with applications to polymers, DNA enzyme mechanisms, and protein structure and function. The contents is based on contributions presented at the International Conference on Knots, Low-Dimensional Topology and Applications - Knots in Hellas 2016, which was held at the International Olympic Academy in Greece in July 2016. The goal of the international conference was to promote the exchange of methods and ideas across disciplines and generations, from graduate students to senior researchers, and to explore fundamental research problems in the broad fields of knot theory and low-dimensional topology. This book will benefit all researchers who wish to take their research in new directions, to learn about new tools and methods, and to discover relevant and recent literature for future study.