|
Showing 1 - 5 of
5 matches in All Departments
This book focuses on the role of the endocannabinoid system in
local and systemic inflammation, with individual chapters written
by experts in the field of cannabinoid research and medicine. The
topics explore the actions of the endocannabinoid system on the
immune system, including neuroinflammation in autoimmune disorders
such as multiple sclerosis, and in neurodegenerative disorders such
as Huntington's and Alzheimer's, as well as local and systemic
inflammatory conditions affecting organs including the eye (uveitis
and corneal inflammation), the bladder (interstitial cystitis),
pancreas (diabetes), cardiovascular system (stroke), joints
(arthritis), and sepsis. The objective of this book is to provide
knowledge transfer on the use of cannabinoids in inflammatory
disease by critically examining preclinical and clinical research
on the immunomodulatory actions of the endocannabinoid system, with
specific emphasis on the actions of cannabinoids in diseases where
inflammation is a prominent component. By drawing these results
together, we seek to provide further understanding of the
complexities of endocannabinoid system modulation of immune
function and identify potential uses and limitations for
cannabinoid-based therapeutics.
Sepsis is a life-threatening organ dysfunction caused by a
dysregulated host response to infection. Variability in
pathogenesis and complex pathophysiology often delay diagnosis and
create significant challenges for clinical studies in this group of
critically ill patients. Mainly for those reasons, there is no
therapy approved so far to overcome the underlying immune
dysregulation. This book provides an overview about the state of
the art of sepsis diagnostics and potential future therapies.
Chapter 1 focuses on the immunologic staging of sepsis-the key for
successful treatment of the dysregulated hot response. Chapter 2
reveals similarities in the immune response in sepsis and
cancer-opening new avenues for novel therapies. Chapter 3
introduces an important modulator of the immune response-the
endogenous cannabinoid system and elucidates its role in organ
dysfunction in sepsis. Facing the increasing bacterial resistance
to classical antibiotics, Chapter 4 discusses two unique mechanisms
to treat infection and inflammation in sepsis: iron chelation, and
the sphingosine pathway. The authors, all experts in experimental
and clinical sepsis research, seek to provide further understanding
of the complexities of the immune response as the physiological
basis for the development of new therapeutics in sepsis.
This book focuses on the role of the endocannabinoid system in
local and systemic inflammation, with individual chapters written
by experts in the field of cannabinoid research and medicine. The
topics explore the actions of the endocannabinoid system on the
immune system, including neuroinflammation in autoimmune disorders
such as multiple sclerosis, and in neurodegenerative disorders such
as Huntington's and Alzheimer's, as well as local and systemic
inflammatory conditions affecting organs including the eye (uveitis
and corneal inflammation), the bladder (interstitial cystitis),
pancreas (diabetes), cardiovascular system (stroke), joints
(arthritis), and sepsis. The objective of this book is to provide
knowledge transfer on the use of cannabinoids in inflammatory
disease by critically examining preclinical and clinical research
on the immunomodulatory actions of the endocannabinoid system, with
specific emphasis on the actions of cannabinoids in diseases where
inflammation is a prominent component. By drawing these results
together, we seek to provide further understanding of the
complexities of endocannabinoid system modulation of immune
function and identify potential uses and limitations for
cannabinoid-based therapeutics.
A major goal of transplantation research is to develop a specific
immune unresponsiveness to alloantigen. Oral administration of
antigen prior to systemic challenge has been demonstrated to
suppress systemic immune responses, and this antigen specific
suppression is termed oral tolerance. This book assesses whether
oral tolerance can be used to prolong kidney allograft survival and
investigates the mechanisms by which this survival is prolonged.
The book described that oral exposure to alloantigen prolongs
kidney allograft survival in rats in an allospecific manner. The
prolongation is due to a generation of CD8+ T regulatory (Treg)
cells in the recipient. The CD8+ Treg cells are present in the
spleen, mesenteric lymph nodes and kidney allograft and able to
transfer the graft prolongation to nave recipient. These Treg cells
may shift immune responses towards type 2 responses and delete
alloreactive T lymphocytes through Fas/FasL interaction.
|
|