This book constitutes the refereed proceedings of the 16th International Conference on Computer-Aided Architectural Design Futures, CAAD Futures 2015, held in Sao Paulo, Brazil, in July 2015. The 33 revised full papers presented were carefully reviewed and selected from 200 submissions. The papers are organized in topical sections on modeling, analyzing and simulating the city; sustainability and performance of the built space; automated and parametric design; building information modelling (BIM); fabrication and materiality; shape studies.