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Although long known as a parasite of medical and veterinary
importance, interest in Toxoplasma gondii has increased with its
emergence as a major cause of death in immunosuppressed
individuals, and with recognition of its suitability as a model
system for molecular and cellular investigations of apicomplexan
parasites. The NATO workshop brought together 32 scientists working
in different areas of toxoplasmosis research to gain an overview of
progress in the field. Molecular studies have been carried out on
genomic and extrachromosomal DNA. They reveal that Toxoplasma is
very highly conserved, genetic mapping is underway and preliminary
linkage analysis suggests recombination is rare; moreover all
virulent strains share the same isoenzyme markers and are seen to
be essentially clonal by RFLP analysis [Boothroyd, Darde, Wilson].
Despite considerable structural homology between Toxoplasma and
related apicomplexan parasites there is little direct overlap in
gene sequence data. Good progress has been made in cloning
functional genes and in elucidation of PI anchors [Cesbron-Delauw,
Johnson, Mercereau-Puijalon, Striepen]. The structure of molecules
on the surface and within dense granules, rhoptries and micronemes
has in some cases been determined and provides clues as to the
targetting and function of these proteins.
A son of poor Jamaican immigrants who grew up in Depression-era
Harlem, Harry Belafonte became the first black performer to gain
artistic control over the representation of African Americans in
commercial television and film. Forging connections with an
astonishing array of consequential players on the American scene in
the decades following World War II-from Paul Robeson to Ed
Sullivan, John Kennedy to Stokely Carmichael-Belafonte established
his place in American culture as a hugely popular singer, matinee
idol, internationalist, and champion of civil rights, black pride,
and black power. In Becoming Belafonte, Judith E. Smith presents
the first full-length interpretive study of this multitalented
artist. She sets Belafonte's compelling story within a history of
American race relations, black theater and film history,
McCarthy-era hysteria, and the challenges of introducing
multifaceted black culture in a moment of expanding media
possibilities and constrained political expression. Smith traces
Belafonte's roots in the radical politics of the 1940s, his careful
negotiation of the complex challenges of the Cold War 1950s, and
his full flowering as a civil rights advocate and internationally
acclaimed performer in the 1960s. In Smith's account, Belafonte
emerges as a relentless activist, a questing intellectual, and a
tireless organizer. From his first national successes as a singer
of Calypso-inflected songs to the dedication he brought to
producing challenging material on television and film regardless of
its commercial potential, Belafonte stands as a singular figure in
American cultural history-a performer who never shied away from the
dangerous crossroads where art and politics meet.
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