This book constitutes revised selected papers from the 15th Workshop on e-Business, WeB 2016, held in conjunction with the International Conference on Information Systems, ICIS, in Dublin, Ireland, in December 2016. WeB 2016 provided a forum for scholars to exchange ideas and share results from their research. Original articles addressing a broad coverage of technical, managerial, economic, and strategic issues related to consumers, businesses, industries, and governments were presented at the workshop, employing various IS research methods such as case study, survey, analytical modeling, experiments, computational models, and design science. The 15 full and 8 short papers presented in this volume were carefully reviewed and selected from 46 submissions. They deal with the "Internetworked World" focusing on digitalization, consumerization, global platforms, and transformative innovations in industry.