Since the publication of The New Science of Astrobiology in the year 2001-the first edition of the present book-two significant events have taken place raising the subject from the beginning of the present century to its present maturity. Firstly, in 2001 the Galileo Mission still had two years to complete its task, which turned out to be an outstanding survey of the Jovian system, especially of its intriguing satellite Europa. Secondly, the Cassini Huygens Mission was still on its way to Saturn. Its present success has surpassed all expectations of ESA and NASA. Astrobiologists still did not know that Titan was the fifth body in the Solar System that possibly contained a water ocean (including the Earth and the three Galilean satellites other than Io). For these reasons the book includes overviews of the evolutionary and molecular biology that are necessary. There is a discussion of other sectors of culture that are the natural frontiers of astrobiology, especially the humanities.

The Sixth Trieste Conference on Chemical Evolution for the first time has also been a Euroconference. This year we focused on "First Steps in the Origin of Life in the Universe". (Both this Centre and the ICGEB have been sponsors since we first started planning the series with Professors Abdus Salam and Cyril Ponnamperuma. ) The conference had the following 11 sponsors: The Abdus Salam International Centre for Theoretical Physics, The European Commission, The SETI Institute, Consiglio Nazionale delle Ricerche, Rome, Italy, The International Centre for Genetic Engineering and Biotechnology, Trieste, The European Space Agency (ESA), National Aeronautics and Space Administration (NASA) Universite Paris 12, The ICTP Public Information Office, La Fondazione Internazionale Trieste per il Progresso e la Liberta della Scienza, and II Laboratorio dell'Immaginario Scientifico. of our Over 90 participants allowed us to make a truly comprehensive review subject. In 82 presentations we had contributions from experts in questions related to the origin, evolution, distribution and destiny of life in the universe, topics that are known together as the science ofastrobiology. The publication ofthese proceedings was largely due to a generous grant form the Consiglio Nazionale delle Ricerche, Rome, Italy. The general topic of the conference concerned the origin, evolution, distribution and destiny of life in the Universe, a subject referred to as astrobiology and also as exobiology. In this report we prefer the synonym Astrobiology.

The proposal of the School was made in 1998 to three institutions, which responded enthusiastically: The Abdus Salam International Centre for Theoretical Physics (ICTP), its main co-sponsor, the International Centre for Genetic Engineering and Biotechnology, both in Trieste, Italy, and the Chancellor's Office, Universidad Simon Bolfvar (USB). The secretarial and logistic support was provided in Trieste by the ICTP and in Caracas by USB and the IDEA Convention Center. In addition the event was generously supported by the following institutes, agencies, foundations and academies: NASA Headquarters, European Space Agency, TALVEN Programme, (Delegacion Permanente de Venezuela ante la UNESCO), The SETI Institute, Centro Latinoamericano .de Ffsica, The Third World Academy of Sciences, Academia de Ciencias Ffsicas, Matematicas y Naturales, Red Latinoamericana de Biologfa, The Planetary Society, The Latin American Academy of Sciences (Fondo ACAL), Alberto Vollmer Foundation, Inc, Fundacion J. Oro, Associated to the Catalonian Research Foundation, Red Latinoamericana de Astronomfa and Colegio Emil Friedman. A total of 36 lectures were delivered by 20 lecturers, of which 14 were from the following countries: Argentina, Mexico, Italy, Spain and the USA. Six lecturers were from the host country. In addition there were 5 chairpersons from the host country that were not participants; two participants acted as chairpersons (Pedro Benitez and Tomas Revilla).

This interdisciplinary book consists of the proceedings of the Alexander Ivanovich Oparin lOOth Anniversary Conference, The Third Trieste Conference on Chemical Evolution, which took place at the International Centre for Theoretical Physics from 29 August till 2 September, 1994. A general overview of Oparin's life and work is followed by a review of Alfonso Herera, another pioneer in the studies of the origin of life. The subject matter is organized in ten sections corresponding to various aspects of our current understanding of the subject that was initiated by Oparin. These subjects were covered by fifty three speakers. There were sixty seven participants from a wide geographical distribution; twenty seven countries were represented. We have included the invited lecture of Professor Igor Kulaev, who was unable to be present at the conference for reasons beyond his control. The conference was generously supported by the International Centre for Theoretical Physics, the Commission of the European Communities, the International Centre for Genetic Engineering and Biotechnology, the International Centre for Science and High Technology, and UNESCO. Cyril Ponnamperuma, University of Maryland, U.S.A. Julian Chela-Flores, ICTP, Italy, and IDEA, Venezuela. xi FOREWORD As this volume was going to press we learnt of the untimely death of Cyril Ponnamperuma who died of cardiac arrest on December 20, 1994.

Leading researchers in the area of the origin and evolution of life in the universe contributed to Chemical Evolution: Physics of the Origin and Evolution of Life. This volume provides a review of this interdisciplinary field. In 35 chapters many aspects of the origin of life are discussed by 90 authors, with particular emphasis on the early paleontological record: physical, chemical, biological, and informational aspects of life's origin, instrumentation in exobiology and system exploration; the search for habitable planets and extraterrestrial intelligent radio signals. This book contains the proceedings of the Fourth Trieste Conference on Chemical Evolution that took place in September 1995, in which scientists from a wide geographical distribution joined in a Memorial to Cyril Ponnamperuma, who was a pioneer in the field of chemical evolution, the origin of life, and exobiology, and also initiated the Trieste Conferences on Chemical Evolution and the Origin of Life. This fourth Conference was therefore dedicated to his memory. Audience: Graduate students and researchers in the many areas of basic, earth, and life sciences that contribute to the study of chemical evolution and the origin of life.

Since the publication of The New Science of Astrobiology in the year 2001 the first edition of the present book two significant events have taken place raising the subject from the beginning of the present century to its present maturity. Firstly, in 2001 the Galileo Mission still had two years to complete its task, which turned out to be an outstanding survey of the Jovian system, especially of its intriguing satellite Europa. Secondly, the Cassini Huygens Mission was still on its way to Saturn. Its present success has surpassed all expectations of ESA and NASA. Astrobiologists still did not know that Titan was the fifth body in the Solar System that possibly contained a water ocean (including the Earth and the three Galilean satellites other than Io). For these reasons the book includes overviews of the evolutionary and molecular biology that are necessary. There is a discussion of other sectors of culture that are the natural frontiers of astrobiology, especially the humanities."

H. BALTSCHEFFSKYChairman Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, S-106 91 Stockholm, Sweden. Professor Stanley Miller, Professor K. R. Srinivasan, Organizers and Sponsors of this Conference, Ladies and Gentlemen; WearegettingreadyfortheAbdusSalamLecture, honoringtwomostdistinguishedsci- tists. Bothhaveverysigni?cantlycontributedtotherapidgrowthofthesphereoffun- mentalknowledgeinthesecondhalfofthetwentiethcentury. Abdus Salam, theoreticalphysicist, NobelPrizewinner, creatorandlongtimeleader of The Abdus Salam Center of Theoretical Physics. With his active interest in the origin oflifeheplayedaleadingroleininstigatingtheseconferencesonChemicalEvolutionand theOriginofLifehereinTrieste, whichstillareofsuchprimaryimportanceinthis?eld. Heleftthisworldin1996. And Stanley Miller, whomostgenerously, astheAbdusSalamLecturer, isgoingto giveushis"Recollectionsofthebeginningofchemicalevolutionexperiments" DearStanley, itisagreatprivilege, andindeedapleasuretointroduceyou. Thisisina wayaquiteeasytask, becauseweallalreadyknowthat"theMillerexperiment,"whichis mostappropriatelyplacedinthetitleofthisconference, in1953, exactly50yearsago, was amajorbreakthrough, openingupanewresearch?eldwith, andfor, rationalandadvanced chemicalexperimentationonthemolecularoriginoflife. Itwouldtaketoomuchtimetotrytodescribehereyourscienti?ccarrier, yourprices, yourPresidencyofISSOLandyourmanyothersuccesses. SoIratherwillendthisint- ductionwithacoupleofpersonalrecollections. First I would like to combine something of Abdus Salam and Stanley Miller. Abdus Salamgavethevery?rstinvitedlectureoftheUniversityofStockholmInternationalL- turesonHuman, GlobalandUniversalProblems, in1975. And10yearslater, atLidingo ] closetoStockholm, StanleyMillergavetheopeninglectureofaconferenceontheMol- ularEvolutionofLife. OnapictureItook, asaco-arrangeroftheseevents, Stanleyisseen approachinginhisusual, modestway, morefocussedonscienti?cdiscussionthanonthe camera. Last but not least, I shall tell you the true story about when we learned that Stanley isanenthusiasticenvironmentalist, inthebestsenseoftheword. About25yearsago, in Stockholm, Stanley, my wife and I strolled in the King's Garden. Its elmtrees were full 7 J. Seckbach et al. (eds. ), Life in the Universe,7-8. C 2004 Kluwer Academic Publishers. Printed in the Netherlands. 8 of young people who, some even spending nights in the trees, prevented the authorities from removing the elmtrees, by ax and saw. Also Stanley signed a petition to save the elmtrees-andtheyweresaved Stanley, I believe that your greatness as a scientist and as a friend must be linked to the many facets of your wonderful personality. We much look forward to your lecture. THE BEGINNING OF CHEMICAL EVOLUTION EXPERIMENTS Recollections and Perspectives 1 2 3 S. L. MILLER, J. L. BADA, and A."

Astrobiology is a very broad interdisciplinary field covering the origin, evolution, distribution, and destiny of life in the universe, as well as the design and implementation of missions for solar system exploration. A review covering its complete spectrum has been missing at a level accessible even to the non-specialist.
The last section of the book consists of a supplement, including a glossary, notes, and tables, which represent highly condensed windows' into research ranging from basic sciences to earth and life sciences, as well as the humanities.
These additions should make The New Science of Astrobiology accessible to a wide readership: scientists, humanists, and the general reader will have an opportunity to participate in one of the most rewarding activities of contemporary culture.

Astrobiology is a very broad interdisciplinary field covering the origin, evolution, distribution, and destiny of life in the universe, as well as the design and implementation of missions for solar system exploration. A review covering its complete spectrum has been missing at a level accessible even to the non-specialist.
The last section of the book consists of a supplement, including a glossary, notes, and tables, which represent highly condensed windows' into research ranging from basic sciences to earth and life sciences, as well as the humanities.
These additions should make The New Science of Astrobiology accessible to a wide readership: scientists, humanists, and the general reader will have an opportunity to participate in one of the most rewarding activities of contemporary culture.

The proposal of the School was made in 1998 to three institutions, which responded enthusiastically: The Abdus Salam International Centre for Theoretical Physics (ICTP), its main co-sponsor, the International Centre for Genetic Engineering and Biotechnology, both in Trieste, Italy, and the Chancellor's Office, Universidad Simon Bolfvar (USB). The secretarial and logistic support was provided in Trieste by the ICTP and in Caracas by USB and the IDEA Convention Center. In addition the event was generously supported by the following institutes, agencies, foundations and academies: NASA Headquarters, European Space Agency, TALVEN Programme, (Delegacion Permanente de Venezuela ante la UNESCO), The SETI Institute, Centro Latinoamericano .de Ffsica, The Third World Academy of Sciences, Academia de Ciencias Ffsicas, Matematicas y Naturales, Red Latinoamericana de Biologfa, The Planetary Society, The Latin American Academy of Sciences (Fondo ACAL), Alberto Vollmer Foundation, Inc, Fundacion J. Oro, Associated to the Catalonian Research Foundation, Red Latinoamericana de Astronomfa and Colegio Emil Friedman. A total of 36 lectures were delivered by 20 lecturers, of which 14 were from the following countries: Argentina, Mexico, Italy, Spain and the USA. Six lecturers were from the host country. In addition there were 5 chairpersons from the host country that were not participants; two participants acted as chairpersons (Pedro Benitez and Tomas Revilla).

Leading researchers in the area of the origin, evolution and distribution of life in the universe contributed to Exobiology: Matter, Energy, and Information in the Origin and Evolution of Life in the Universe. This volume provides a review of this interdisciplinary field. In 50 chapters many aspects that contribute to exobiology are reviewed by 90 authors. These include: historical perspective of biological evolution; cultural aspects of exobiology, cosmic, chemical and biological evolution, molecular biology, geochronology, biogeochemistry, biogeology, and planetology. Some of the current missions are discussed. Other subjects in the frontier of exobiology are reviewed, such as the search for planets outside the solar system, and the possible manifestation of intelligence in those new potential environments. The SETI research effort is well represented in this general overview of exobiology. This book is the proceedings of the Fifth Trieste Conference on Chemical Evolution that took place in September 1997. The volume is dedicated to the memory of Nobel Laureate Abdus Salam who suggested the initiation of the Trieste conferences on chemical evolution and the origin of life. Audience: Graduate students and researchers in the many areas of basic, earth, and life sciences that contribute to the study of chemical evolution and the origin, evolution and distribution of life in the universe.

Leading researchers in the area of the origin and evolution of life in the universe contributed to Chemical Evolution: Physics of the Origin and Evolution of Life. This volume provides a review of this interdisciplinary field. In 35 chapters many aspects of the origin of life are discussed by 90 authors, with particular emphasis on the early paleontological record: physical, chemical, biological, and informational aspects of life's origin, instrumentation in exobiology and system exploration; the search for habitable planets and extraterrestrial intelligent radio signals. This book contains the proceedings of the Fourth Trieste Conference on Chemical Evolution that took place in September 1995, in which scientists from a wide geographical distribution joined in a Memorial to Cyril Ponnamperuma, who was a pioneer in the field of chemical evolution, the origin of life, and exobiology, and also initiated the Trieste Conferences on Chemical Evolution and the Origin of Life. This fourth Conference was therefore dedicated to his memory. Audience: Graduate students and researchers in the many areas of basic, earth, and life sciences that contribute to the study of chemical evolution and the origin of life.

This interdisciplinary book consists of the proceedings of the Alexander Ivanovich Oparin lOOth Anniversary Conference, The Third Trieste Conference on Chemical Evolution, which took place at the International Centre for Theoretical Physics from 29 August till 2 September, 1994. A general overview of Oparin's life and work is followed by a review of Alfonso Herera, another pioneer in the studies of the origin of life. The subject matter is organized in ten sections corresponding to various aspects of our current understanding of the subject that was initiated by Oparin. These subjects were covered by fifty three speakers. There were sixty seven participants from a wide geographical distribution; twenty seven countries were represented. We have included the invited lecture of Professor Igor Kulaev, who was unable to be present at the conference for reasons beyond his control. The conference was generously supported by the International Centre for Theoretical Physics, the Commission of the European Communities, the International Centre for Genetic Engineering and Biotechnology, the International Centre for Science and High Technology, and UNESCO. Cyril Ponnamperuma, University of Maryland, U.S.A. Julian Chela-Flores, ICTP, Italy, and IDEA, Venezuela. xi FOREWORD As this volume was going to press we learnt of the untimely death of Cyril Ponnamperuma who died of cardiac arrest on December 20, 1994.

Leading researchers in the area of the origin, evolution and distribution of life in the universe contributed to Exobiology: Matter, Energy, and Information in the Origin and Evolution of Life in the Universe. This volume provides a review of this interdisciplinary field. In 50 chapters many aspects that contribute to exobiology are reviewed by 90 authors. These include: historical perspective of biological evolution; cultural aspects of exobiology, cosmic, chemical and biological evolution, molecular biology, geochronology, biogeochemistry, biogeology, and planetology. Some of the current missions are discussed. Other subjects in the frontier of exobiology are reviewed, such as the search for planets outside the solar system, and the possible manifestation of intelligence in those new potential environments. The SETI research effort is well represented in this general overview of exobiology. This book is the proceedings of the Fifth Trieste Conference on Chemical Evolution that took place in September 1997. The volume is dedicated to the memory of Nobel Laureate Abdus Salam who suggested the initiation of the Trieste conferences on chemical evolution and the origin of life. Audience: Graduate students and researchers in the many areas of basic, earth, and life sciences that contribute to the study of chemical evolution and the origin, evolution and distribution of life in the universe.

H. BALTSCHEFFSKYChairman Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, S-106 91 Stockholm, Sweden. Professor Stanley Miller, Professor K. R. Srinivasan, Organizers and Sponsors of this Conference, Ladies and Gentlemen; WearegettingreadyfortheAbdusSalamLecture, honoringtwomostdistinguishedsci- tists. Bothhaveverysigni?cantlycontributedtotherapidgrowthofthesphereoffun- mentalknowledgeinthesecondhalfofthetwentiethcentury. Abdus Salam, theoreticalphysicist, NobelPrizewinner, creatorandlongtimeleader of The Abdus Salam Center of Theoretical Physics. With his active interest in the origin oflifeheplayedaleadingroleininstigatingtheseconferencesonChemicalEvolutionand theOriginofLifehereinTrieste, whichstillareofsuchprimaryimportanceinthis?eld. Heleftthisworldin1996. And Stanley Miller, whomostgenerously, astheAbdusSalamLecturer, isgoingto giveushis"Recollectionsofthebeginningofchemicalevolutionexperiments" DearStanley, itisagreatprivilege, andindeedapleasuretointroduceyou. Thisisina wayaquiteeasytask, becauseweallalreadyknowthat"theMillerexperiment,"whichis mostappropriatelyplacedinthetitleofthisconference, in1953, exactly50yearsago, was amajorbreakthrough, openingupanewresearch?eldwith, andfor, rationalandadvanced chemicalexperimentationonthemolecularoriginoflife. Itwouldtaketoomuchtimetotrytodescribehereyourscienti?ccarrier, yourprices, yourPresidencyofISSOLandyourmanyothersuccesses. SoIratherwillendthisint- ductionwithacoupleofpersonalrecollections. First I would like to combine something of Abdus Salam and Stanley Miller. Abdus Salamgavethevery?rstinvitedlectureoftheUniversityofStockholmInternationalL- turesonHuman, GlobalandUniversalProblems, in1975. And10yearslater, atLidingo ] closetoStockholm, StanleyMillergavetheopeninglectureofaconferenceontheMol- ularEvolutionofLife. OnapictureItook, asaco-arrangeroftheseevents, Stanleyisseen approachinginhisusual, modestway, morefocussedonscienti?cdiscussionthanonthe camera. Last but not least, I shall tell you the true story about when we learned that Stanley isanenthusiasticenvironmentalist, inthebestsenseoftheword. About25yearsago, in Stockholm, Stanley, my wife and I strolled in the King's Garden. Its elmtrees were full 7 J. Seckbach et al. (eds. ), Life in the Universe,7-8. C 2004 Kluwer Academic Publishers. Printed in the Netherlands. 8 of young people who, some even spending nights in the trees, prevented the authorities from removing the elmtrees, by ax and saw. Also Stanley signed a petition to save the elmtrees-andtheyweresaved Stanley, I believe that your greatness as a scientist and as a friend must be linked to the many facets of your wonderful personality. We much look forward to your lecture. THE BEGINNING OF CHEMICAL EVOLUTION EXPERIMENTS Recollections and Perspectives 1 2 3 S. L. MILLER, J. L. BADA, and A."

The Sixth Trieste Conference on Chemical Evolution for the first time has also been a Euroconference. This year we focused on "First Steps in the Origin of Life in the Universe." (Both this Centre and the ICGEB have been sponsors since we first started planning the series with Professors Abdus Salam and Cyril Ponnamperuma. ) The conference had the following 11 sponsors: The Abdus Salam International Centre for Theoretical Physics, The European Commission, The SETI Institute, Consiglio Nazionale delle Ricerche, Rome, Italy, The International Centre for Genetic Engineering and Biotechnology, Trieste, The European Space Agency (ESA), National Aeronautics and Space Administration (NASA) Universite Paris 12, The ICTP Public Information Office, La Fondazione Internazionale Trieste per il Progresso e la Liberta della Scienza, and II Laboratorio dell'Immaginario Scientifico. of our Over 90 participants allowed us to make a truly comprehensive review subject. In 82 presentations we had contributions from experts in questions related to the origin, evolution, distribution and destiny of life in the universe, topics that are known together as the science ofastrobiology. The publication ofthese proceedings was largely due to a generous grant form the Consiglio Nazionale delle Ricerche, Rome, Italy. The general topic of the conference concerned the origin, evolution, distribution and destiny of life in the Universe, a subject referred to as astrobiology and also as exobiology. In this report we prefer the synonym Astrobiology.

This book reviews the horizons and frontiers of humanism as they interact with the science of life in the universe, now generally known as "astrobiology". As one of the most important conversations of our time, the existence of life itself raises deep questions that are meaningful to both astrobiology and humanism. The text discusses current disagreements in this intercultural dialogue, which are shown to be solely due to the widespread delusion that the horizons and frontiers of science can be ignored.