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Chemistry. Tetrahydrobiopterin Dependent Hydroxylases.
Tetrahydrobiopterin Regenerating Enzymes. Tetrahydrobiopterin
Biosynthesis. Tetrahydrobiopterin Regulation. Tetrahydrobiopterin
Deficiency. Nitric Oxide Synthase. Other Functions of
Tetrahydrobiopterins. Molybdopterin Cofactors. Synthesis and
Biological Evaluation of AntiFolates. Dihydrofolate Reductase.
Thymidylate Synthase. Folylpolyglutamate Synthetase and Hydrolase.
OneCarbon Metabolism. Folate Nutrition and Transport. 165 articles.
Index.
The pteridines in their multitude of forms fulfill many roles in
nature ranging from pigments to cofactors for numerous redox and
one-carbon transfer reactions. This extraordinary diversity of
function is unified by the unique chemistry of the pteridine
heterocycle. The International Symposium on the Chemistry and
Biology of Pteridines and Folates is a forum for presenting recent
and exciting advances in this expanding field. In of ideas results
that has often stimulated bringing together various disciplines, a
synergy fresh approaches to major problems. The Tenth International
Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved
no exception by providing new insights into folate enzymology,
tetrahydrobiopterin and molybdopterin biosynthesis and function,
enzyme synthesis and regulation, along with novel synthetic
strategies for producing compounds that will expedite further
study. The many outstanding scientific contributions found in the
following chapters, which represent the work presented at the
Symposium, are a reflection of the significant advances made since
the Ninth International Symposium held in Zurich in 1989. Since the
7th International Symposium in St. Andrews, Scotland, a tradition
has evolved of honoring scientists who have made outstanding
contributions to pteridine research with a Gowland Hopkins medal
and lectureship. Sir Frederick Gowland Hopkins initiated the first
investigation of what later proved to be pteridines in his studies
of the yellow and white colors of butterflies.
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