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It has been reported that many tested and established antibiotics
does not perform well in general and sometimes it is totally
ineffective in specific cases. This inactiveness is inhibited by
presence of some unwanted proteins received from different origins.
In the present book one of such enzymes named NDM-1, its behavior
and hindrance characteristics in the working of certain group of
antibiotics wiz. A Carbapenem antibiotic has been addressed
thoroughly. The mechanism of hindrance to particular group of drugs
especially Polymyxins and Tigecycline antibiotics has been very
frequently observed. To alleviate this undesirable situation
docking of possible drug compounds with diseased proteins has been
exhibited. Further, out of possible drug compounds best drug
compound is identified after docking exercise of drugs over NDM-1.
The best performing drug has been identified as CID 6249,
Stock1n-13321 and CID 2174. The sole purpose of writing this book
is to encourage similar researches. So as the solution of
ineffectiveness of established, very important and life saving
antibiotics may be obtained by and large in wide spectrum.
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