This book takes a multidisciplinary approach to the paradigm of biosurfaces and biomaterials through experts working in the arena of interfacing materials with bio-engineering. Starting with the concepts of biomaterials, the book builds upon the real-life applications elucidating the contrasting requirements of materials in their interfaces with biological environment. A birdseye overview of critical requirements is provided, followed by a description of the fundamental mechanisms of protein adsorption, platelet and cell-adhesion. Case studies on mechanical properties, and laser engineering of surfaces that fulfill the critical requirements in constructing successful implants are included. The concept of non-wetting, required especially for anti-biofouling surfaces, via super-hydrophobicity will be discussed. Ethics, legal issues, and a perspective on the future of the biomaterials field conclude the book.