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The advances in human genetics that have ocurred during the past 20
years have revolutionized our knowledge of the role played by
inheritance in health and disase. It is clear that our DNA
determines not only the emergence of catastrophic single-gene
disorders, which affect millions of persons worldwide, but also
interacts with environments to predispose individuals to cancer,
allergy, hypertension, heart disease, diabetes, psychiatric
disorders and even to some infectious diseases. Overall, the study
of longevity and the demonstration of genes favouring a long
lifespan suggest that such protective systems exist. In recent
years, the study of genetic polymorphisms has made clear that some
alleles have beneficial effects. These discoveries can
substantially improve our understanding of the interactions between
genetics and the environment, between pathogenetic mechanisms and
new treatments.
Incidence and mortality of atherosclerosis and coronary heart
disease (CHD) vary considerably among races, populations and ethnic
groups. Some individuals with low levels of risk factors succumb
early to disease while many others with a high risk profile do not.
CHD clusters in families and is manyfold increased in first degree
relatives of persons with an early onset of the disease. Such
studies provide compelling evidence of the high degree of
heritability of CHD and its risk factors. This book consolidates
the available evidence for the roles of genetics in
atherosclerosis, its correlates and its sequelae. It presents and
discusses the methodology currently used to elucidate the role of
genetics. Separate parts focus on evidence of familial aggregation
and ethnic variability of the disease and on monogenic and
polygenic inheritance modes including all the recent findings and
innovation. The book also contains chapters on the genetic aspects
of vessel wall processes, such as early structural findings in
histological studies and the variability of coronary anatomic
patterns. Polymorphisms at the DNA level (RFLP) are detailed and
reviewed. Directions for future research in the exciting and fast
developing realm of genetic epidemiology are outlined and the major
preventive and public health implications are discussed. Genetic
Factors in Coronary Heart Disease provides a systematic review of
findings, integrated to offer a comprehensive summary and stepping
stone for future research. It will be of interest to investigators
in atherosclerosis, genetics, epidemiology, biostatistics,
cardiology and public health.
Incidence and mortality of atherosclerosis and coronary heart
disease (CHD) vary considerably among races, populations and ethnic
groups. Some individuals with low levels of risk factors succumb
early to disease while many others with a high risk profile do not.
CHD clusters in families and is manyfold increased in first degree
relatives of persons with an early onset of the disease. Such
studies provide compelling evidence of the high degree of
heritability of CHD and its risk factors. This book consolidates
the available evidence for the roles of genetics in
atherosclerosis, its correlates and its sequelae. It presents and
discusses the methodology currently used to elucidate the role of
genetics. Separate parts focus on evidence of familial aggregation
and ethnic variability of the disease and on monogenic and
polygenic inheritance modes including all the recent findings and
innovation. The book also contains chapters on the genetic aspects
of vessel wall processes, such as early structural findings in
histological studies and the variability of coronary anatomic
patterns. Polymorphisms at the DNA level (RFLP) are detailed and
reviewed. Directions for future research in the exciting and fast
developing realm of genetic epidemiology are outlined and the major
preventive and public health implications are discussed. Genetic
Factors in Coronary Heart Disease provides a systematic review of
findings, integrated to offer a comprehensive summary and stepping
stone for future research. It will be of interest to investigators
in atherosclerosis, genetics, epidemiology, biostatistics,
cardiology and public health.
This book offers an integrative examination of the role of
motivation in shaping moral cognition, judgment, and behavior. How
do we define good and bad? Where do our moral systems originate?
These questions have long sparked inquiry across multiple
disciplines, and scholars have debated the answer both within and
across fields for centuries. Contributors examine the sociocultural
context of morality including norms and norm compliance;
psychological frameworks that underlie virtuous behavior and help
navigate competing moral obligations; the neurobiology of moral
reasoning, and more. In bringing together leading researchers
across sociology, philosophy, psychology, and neuroscience, this
book explains the complex motivational aspects of morality, which
represents a crucial step toward understanding how and why our
moral choices arise, and in turn can shape and guide how we engage
in the daily practice of morality.
The life long close friendship of five very different, but strong
women. Their families, and the men in their lives. Throw in secret
sexual cravings, lies, unfulfilled desires and a suspicious death;
and you ( the reader ) have to keep reminding yourself to breathe
Philosophy of Technology is a collection of short interviews based
on 5 questions presented to some of the most influential and
prominent scholars in this field. We hear their views on
technology, its aim, scope, use, the future, and how their work
fits in these respects.
The advances in human genetics that have ocurred during the past 20
years have revolutionized our knowledge of the role played by
inheritance in health and disase. It is clear that our DNA
determines not only the emergence of catastrophic single-gene
disorders, which affect millions of persons worldwide, but also
interacts with environments to predispose individuals to cancer,
allergy, hypertension, heart disease, diabetes, psychiatric
disorders and even to some infectious diseases. Overall, the study
of longevity and the demonstration of genes favouring a long
lifespan suggest that such protective systems exist. In recent
years, the study of genetic polymorphisms has made clear that some
alleles have beneficial effects. These discoveries can
substantially improve our understanding of the interactions between
genetics and the environment, between pathogenetic mechanisms and
new treatments.
Was wurdest Du tun, lieber Leser, wenn Dir uber Nacht eine
besondere Gabe verliehen wurde? Nimmst Du es ebenfalls alles andere
als leicht? Helmut steht mit beiden Beinen im Leben. Liebt seine
Arbeit und seine Freundin. Ein Geschenk zu seinem vierzigsten
Geburtstag bringt ihn allerdings vollig aus dem Tritt. Plotzlich
ist alles anders. Und die folgenden Tage lassen den Vierzigjahrigen
im wahrsten Sinne des Wortes abheben. Willkommen in Helmuts Welt
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