With remarkable progress being reported in living donor liver transplants and small bowel transplantation, the 9th Keio International Symposium for Life Sciences and Medicine was auspiciously timed. Titled "Current Issues in Liver/Small Bowel Transplantation," the Tokyo symposium brought together researchers from Japan and other parts of the world. This volume is a compilation of papers from the symposium, organized into five key areas of interest to medical professionals: Technical aspects and physiological problems in split/living donor liver transplantation; Viral hepatitis and liver transplantation; Current status and future prospects in small bowel transplantation; Liver transplantation for malignant hepatic tumors; and Novel strategies in immunosuppression. Containing the most up-to-date information on these vital issues, the book is an essential resource for all researchers and practitioners concerned with liver and small bowel transplantation.

The editors of the Philosophy and Medicine series recognize with grat itude the foresight, understanding, hard labor, and patience of Prof. Kazumasa Hoshino. It is his perseverance that has made this volume a reality. It was his faith in ideas that brought together a cluster of scholars in Tokyo on September 2-4, 1994, at Sophia University for a U. S. -J apan Bioethics Congress. With the support of the Foundation for Advance ment of International Science, the Japan Foundation Center for Global Partnership, the Foundation of Thanatology, the Japanese Center for Quality of Life Studies, and Sophia University, scholars from Canada, Germany, Japan, and the United States were able to explore the differ ences and similarities in their approaches to bioethics and health care policy. That conference first produced a volume through Shibunkaku Publishers of Kyoto that appeared in 1995 in J apanese: The Dignity of Death, edited by Kazumasa Hoshino. Selections from those materials have been reworked for an English audience and now appear, along with new essays, in this volume. The field of comparative bioethics is only in its infancy. We are deeply grateful to Prof. Kazumasa Hoshino, one of the fathers of J apanese bioethics, for having made this volume possible. H. Tristram Engelhardt, Jr. Stuart F. Spicker Vll ACKNOWLEDGEMENTS This volume's editors and Kluwer Academic Publishers wish to thank Shibunkaku Press, Kyoto, Japan, for permission to publish, without charge, essays derived from the U. S."

In Japan, cadaveric donor liver transplantation is not common even though cadaveric organ transplantation was legally established in 1998. In contrast, the number of living donor liver transplantations is increasing, with more than 1700 cases at 43 Japanese institutes by November 2001. Indications for and have become living donor liver transplantation are widening in Japan similar to those for cadaveric donor liver transplantation in the United States and Europe. At the same time, split liver transplantation from cadaveric donors shares some technical aspects with living donor liver transplantation. Remarkable progress has been reported recently, and thus it was an auspicious time to hold a symposium on "Current issues in liver/small bowel transplantation" in Japan. We were honored to hold a very fruitful symposium sponsored by the Keio University Medical Science Fund and to bring together top-rank transplant surgeons from Japan and other countries. It was a productive and rewarding time for all participants. We were able to share our experience through excellent presentations followed by active discussions and insightful com ments. At the symposium, we focused on current issues in liver transplanta tion such as widening indications for viral hepatitis and malignant tumors. We also discussed technical aspects and physiological problems in split/iiving donor liver transplant, novel strategies in immunosuppression, and the current status and future prospects in small bowel transplantation. This book contains the papers from all the distinguished guest speakers, focusing on the topics discussed at the symposium."

The editors of the Philosophy and Medicine series recognize with grat itude the foresight, understanding, hard labor, and patience of Prof. Kazumasa Hoshino. It is his perseverance that has made this volume a reality. It was his faith in ideas that brought together a cluster of scholars in Tokyo on September 2-4, 1994, at Sophia University for a U. S. -J apan Bioethics Congress. With the support of the Foundation for Advance ment of International Science, the Japan Foundation Center for Global Partnership, the Foundation of Thanatology, the Japanese Center for Quality of Life Studies, and Sophia University, scholars from Canada, Germany, Japan, and the United States were able to explore the differ ences and similarities in their approaches to bioethics and health care policy. That conference first produced a volume through Shibunkaku Publishers of Kyoto that appeared in 1995 in J apanese: The Dignity of Death, edited by Kazumasa Hoshino. Selections from those materials have been reworked for an English audience and now appear, along with new essays, in this volume. The field of comparative bioethics is only in its infancy. We are deeply grateful to Prof. Kazumasa Hoshino, one of the fathers of J apanese bioethics, for having made this volume possible. H. Tristram Engelhardt, Jr. Stuart F. Spicker Vll ACKNOWLEDGEMENTS This volume's editors and Kluwer Academic Publishers wish to thank Shibunkaku Press, Kyoto, Japan, for permission to publish, without charge, essays derived from the U. S."