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This book presents new mathematics for the description of structure
and dynamics in molecular and cellular biology. On an exponential
scale it is possible to combine functions describing inner
organisation, including finite periodicity, with functions for
outside morphology into a complete definition of structure. This
mathematics is particularly fruitful to apply at molecular and
atomic distances. The structure descriptions can then be related to
atomic and molecular forces and provide information on structural
mechanisms. The calculations have been focussed on lipid membranes
forming the surface layers of cell organelles. Calculated surfaces
represent the mid-surface of the lipid bilayer. Membrane dynamics
such as vesicle transport are described in this new language.
Periodic membrane assemblies exhibit conformations based on the
standing wave oscillations of the bilayer, considered to reflect
the true dynamic nature of periodic membrane structures. As an
illustration the structure of an endoplasmatic reticulum has been
calculated. The transformation of such cell membrane assemblies
into cubosomes seems to reflect a transition into vegetative
states. The organisation of the lipid bilayer of nerve cells is
analyzed, taking into account an earlier observed lipid bilayer
phase transition associated with the depolarisation of the
membrane. Evidence is given for a new structure of the alveolar
surface, relating the mathematical surface defining the bilayer
organisation to new experimental data. The surface layer is
proposed to consist of a coherent phase, consisting of a
lipid-protein bilayer curved according to a classical surface - the
CLP surface. Without employing this new mathematics it would not be
possible to give an analytical description of this structure and
its deformation during the respiration cycle. In more general terms
this mathematics is applied to the description of the structure and
dynamic properties of motor proteins, cytoskeleton proteins, and
RNA/DNA. On a macroscopic scale the motions of cilia, sperm and
flagella are modelled.
This book develops the thesis that structure and function in a variety of condensed systems - from the atomic assemblies in inorganic frameworks and organic molecules, through molecular self-assemblies to proteins - can be unified when curvature and surface geometry are taken together with molecular shape and forces. An astonishing variety of synthetic and biological assemblies can be accurately modelled and understood in terms of hyperbolic surfaces, whose richness and beauty are only now being revealed by applied mathematicians, physicists, chemists and crystallographers. These surfaces, often close to periodic minimal surfaces, weave and twist through space, carving out interconnected labyrinths whose range of topologies and symmetries challenge the imaginative powers. The book offers an overview of these structures and structural transformations, convincingly demonstrating their ubiquity in covalent frameworks from zeolites used for cracking oil and pollution control to enzymes and structural proteins, thermotropic and lyotropic bicontinuous mesophases formed by surfactants, detergents and lipids, synthetic block copolymer and protein networks, as well as biological cell assemblies, from muscles to membranes in prokaryotic and eukaryotic cells. The relation between structure and function is analysed in terms of the previously neglected hidden variables of curvature and topology. Thus, the catalytic activity of zeolites and enzymes, the superior material properties of interpenetrating networks in microstructured polymer composites, the transport requirements in cells, the transmission of nerve signals and the folding of DNA can be more easily understood in the light of this. The text is liberally sprinkled with figures and colour plates, making it accessible to both the beginning graduate student and researchers in condensed matter physics and chemistry, mineralogists, crystallographers and biologists.
The United States House of Representatives is one of the two chambers of the United States Congress; the other is the Senate. Each state receives representation in the House proportional to its population but is entitled to at least one representative; the most populous state, California, currently has 53 representatives. The total number of representatives is currently fixed at 435.[1] Each representative serves for a two-year term. The presiding officer of the House is known as the Speaker, and is elected by the members. This book concentrates on the Committees, Rules and Procedures involved in running this complex organisation.
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