This book is a survey of some aspects of current knowledge on regional Cerebral Blood Flow (rCBF), mainly as studied by the isotope clearance method. Although both theoretical and methodological problems are discussed, attention is mainly dedicated to data obtained from clinical studies. The papers which make up this book were presented at the International Symposium on the Clinical Applications of Isotope Clearance Measurement of Cerebral Blood Flow, held in Mainz, Western Germany, on April 10-12, 1969. The previous meetings on Cerebral Blood Flow, held in Lund in 1964* and in Lund and Copenhagen 1968**, had shown that the moment had come to concentrate on the possibilities of introducing rCBF measurements into clinical routine. This is why in the Mainz Symposium attention was initially focused on methodological aspects. This is also why theoretical problems of physiology of CBF were not emphasized. Finally, this explains why such topics as cerebrovascular disease, head trauma, coma, carotid surgery, brain tumors and intracranial pressure were given pride of place. However a survey of the clinical aspects of rCBF measurements would not be complete without an account of the application of such measurements to monitor cerebral circulatory changes during anesthesia and therapeutic procedures like, for instance, hyperventilation and hyperbaric treatment. Furthermore, it is now possible to obtain data from correlative rCBF studies per formed before, during and after surgical operations on the human brain."

The fourth volume of Progress in Orthopaedic Surgery is somewhat different from pre vious publications of the series. The editors have again tried to present two topics but the publications presented from the European literature are of very recent origin. In the age of total joint replacement it was felt to be imperative to counteract the pre sent tendency to treat every joint which does not seem to be healthy with an artificial re placement. Orthopaedic surgery seems to be influenced by trends. In 1963, E. A. Nichol discussing intracapsular hip fractures, quoted from Alice In Wonderland in an editorial written for volume 45B of the Journal of Bone and Joint Surgery "The Queen had only one way of settling all difficulties, great or small, "Off with his head" ." Today one could paraphrase his implied critizism by saying "Out with the joint." No one doubts that joint replacements have been of great value in treating degenerative joint changes, but it is already apparent that replacement operations are not the ultimate answer for treating every joint deformity. This volume represents the European experience of different types of surgery in treat ing arthrosis of the joints of the lower limb. A reader of the Anglo-American literature will find suggestions in it which reaffirm his uneasiness in considering only one solution for problems concerning lower limb joints. I feel strongly that there are other ways which allow a patient to function well with less extensive operations."

This volume contains the papers presented at the 24th Annual Meeting of the Deutsche Gesellschaft fur Neurochirurgie, held in Mainz, Western Germany, on April 30 - May 3, 1973. Deliberate choice was made of two crucial still hotly debated subjects which, for ages, have meant a source of constant worry, and nights without sleep to every neurosurgeon. Just as long as our special field exists, there have been the problems of how to control brain edema and .of how to reduce lethality and the secondary lesions in surgery of cerebello-pontine angle tumors. Concerning the first subject, new pathological, pathophysiological and chemical aspects, the mechanisms of brain edema formation and resolution are presented in the hope for better understanding. Furthermore, the relationship between brain edema, intracranial pressure, cerebral blood flow and metabolism are discussed. Finally, the therapeutical consequences as well as the results of experimental and clinical work are presented, and a comparison of effects between different methods (hypertonic solutions, diuretics, steroids, controlled hyperventilation, hyperbaric oxygen) is given. Concerning the second main subject, any important contributions to the early diagnosis of cerebello-pontine angle tumors have been included. Nevertheless, it is of utmost interest for the neurosurgeon to know which approach he is to prefer for the different stages of tumor size and to be familiar with the trans labyrinthine approach or the posterior craniotomy, as well as with the importance of the use of the microscope in neurosurgery, the preservation of the facial nerve and, in certain cases, its repair."

Organized by the European Association of Neurosurgical Societies, Paris, July 15-20, 1979