Endoscopic access to the small intestine has long presented a challenge to physicians. This book describes the principles, insertion technique, and clinical applications of double-balloon endoscopy, which will become the gold standard of enteroscopy and which may well eliminate the need for intraoperative enteroscopy in many patients. Leading the way to a new approach, this book provides an invaluable source of reference for all practitioners working in the field.

A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs. A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses: * The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS) * The concept of drug concentration * How to simulate key drug absorption processes * The physiological and drug property data used for biopharmaceutical modeling * Reliable practices for reporting results With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research including running and interpreting models, validation, and compound and formulation selection this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.

Endoscopic access to the small intestine has for a long time presented a challenge to physicians. Although capsule endoscopy can provide an endoscopic image from the entire small intestine, neither biopsy nor endoscopic treatment can be performed with it. In order to make more definitive diagnoses of abnormal findings detected by capsule endoscopy, a new system incorporating greater insertability and maneuverability is required. Double-balloon endoscopy, which enables endoscopic observation of the entire small intestine, represents such a new system. The chapters of this book describe the principles, insertion technique, and clinical applications of double-balloon endoscopy, which will become the gold standard of enteroscopy and may well eliminate the need for intraoperative enteroscopy in many patients. As such, this book will provide an invaluable source of reference for all practitioners working in the field.