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This book is a comprehensive compilation of modern and cutting-edge
chromatographic techniques written by pharmaceutical industry
experts, academics, and vendors in the field. This book is an
inclusive guide to developing all chromatographic methods (such as
liquid chromatography and gas chromatography). It covers modern
techniques for developing methods using chromatographic development
software, requirements for validations, discussion on
orthogonality, and how to transfer methods from HPLC to UHPLC. The
text introduces some newer techniques that are heavily employed by
chemists analyzing proteins and RNAi, as well as novel techniques
such as counter current chromatography. This book is valuable for
both the novice starting out in undergraduate labs and those who
are new to the pharmaceutical industry and is a useful reference
for seasoned analysts.
Analytical chemists in the pharmaceutical industry are always
looking for more-efficient techniques to meet the analytical
challenges of today s pharmaceutical industry. One technique that
has made steady advances in pharmaceutical analysis is
supercritical fluid chromatography (SFC). SFC is meeting the
chromatography needs of the industry by providing efficient and
selective testing capabilities on the analytical and preparative
scale. The supercritical fluid mobile phase, consisting mainly of
CO2, facilitates cost reduction costs and helps the industry in
meeting green chemistry standards. This book provides a
comprehensive overview of the use of SFC in pharmaceutical
analysis.
Supercritical Fluid Chromatography reviews the use of SFC in
drug-discovery applications and describes its application in drug
development. When a drug is developed and brought to market, it is
tested many times for impurities and degradants, enantiomeric
purity, and analytical and preparative isolations it is tested
during discovery and development and for under-regulated and
unregulated methodologies. The book describes the use of SFC for
each of these applications and discusses more in-depth topics, such
as the use of SFC in mass spectrometric and polarographic
detection. The book also sheds light on the role of SFC in drug
development from natural products and the advancement of SFC with
new technologies and its use in pilot-scale operations as a
chromatographic technique.
The accomplishments and enduring influence of renowned
anthropologist Dell Hymes are showcased in these essays by leading
practitioners in the field. Hymes (1927-2009) is arguably best
known for his pioneering work in ethnopoetics, a studied approach
to Native verbal art that elucidates cultural significance and
aesthetic form. As these essays amply demonstrate, nearly six
decades later ethnopoetics and Hymes's focus on narrative
inequality and voice provide a still valuable critical lens for
current research in anthropology and folklore. Through
ethnopoetics, so much can be understood in diverse cultural
settings and situations: gleaning the voices of individual Koryak
storytellers and aesthetic sensibilities from century-old wax
cylinder recordings; understanding the similarities and differences
between Apache life stories told 58 years apart; how Navajo punning
and an expressive device illuminate the work of a Navajo poet;
decolonizing Western Mono and Yokuts stories by bringing to the
surface the performances behind the texts written down by scholars
long ago; and keenly appreciating the potency of language
revitalization projects among First Nations communities in the
Yukon and northwestern California. Fascinating and topical, these
essays not only honor a legacy but also point the way forward.
This book is the first text to provide a comprehensive assessment
of the application of fundamental principles of dissolution and
drug release testing to poorly soluble compounds and formulations.
Such drug products are, vis-a-vis their physical and chemical
properties, inherently incompatible with aqueous dissolution.
However, dissolution methods are required for product development
and selection, as well as for the fulfillment of regulatory
obligations with respect to biopharmaceutical assessment and
product quality understanding. The percentage of poorly soluble
drugs, defined in classes 2 and 4 of the Biopharmaceutics
Classification System (BCS), has significantly increased in the
modern pharmaceutical development pipeline. This book provides a
thorough exposition of general method development strategies for
such drugs, including instrumentation and media selection, the use
of compendial and non-compendial techniques in product development,
and phase-appropriate approaches to dissolution development.
Emerging topics in the field of dissolution are also discussed,
including biorelevant and biphasic dissolution, the use on enzymes
in dissolution testing, dissolution of suspensions, and drug
release of non-oral products. Of particular interest to the
industrial pharmaceutical professional, a brief overview of the
formulation and solubilization techniques employed in the
development of BCS class 2 and 4 drugs to overcome solubility
challenges is provided and is complemented by a collection of
chapters that survey the approaches and considerations in
developing dissolution methodologies for enabling drug delivery
technologies, including nanosuspensions, lipid-based formulations,
and stabilized amorphous drug formulations.
Small Change: Great Impact was written to encourage a small change
in the lives of men that, with the Holy Spirits help, will have a
great impact. If we men would just make a small investment in our
spiritual lives, God will give us a great dividend in return. It is
not how much time we have to live; but more importantly, its what
we do during the time we live. This book is a guide to a 21-day
commitment of a small group or mens boot camp designed to refresh
or revive your life through accountability, dialogue, and biblical
teaching. Its very difficult to get men to be transparent in the
local church. Small Change: Great Impact will help you connect
vertically with God and horizontally with one another while
inspiring you to live a solid Christian life that will impact your
family and the community. Darryl K. Webster is the dutiful pastor
of Emmanuel Missionary Baptist Church in Indianapolis, Indiana. He
is a graduate of Martin University with a Masters degree in Urban
Ministries and a Bachelors degree in Religious Studies. Pastor
Webster is an adjutant professor at Crossroads Bible College where
he also serves as a board trustee and Chair of Student Affairs. He
is also a certified instructor for Proclaiming the Word Ministries.
He strives to instill into his congregation that all believers must
first love God and then serve God by reaching out to others,
exhibiting Christs love in action with daily deeds. Darryl and his
wife, Sibyl, have four children: Quincy, Kristin, Darrin and Kelli.
www.sharingthejoyministries.com
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