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Catecholamines are important transmitter substances in the
autonomic and central nervous systems. These two volumes provide a
comprehensive presentation of the state-of-the-art of catecholamine
research and development in the past 15 years. The volumes present
in-depth reviews of topical areas of catecholamine research in
which substantial progress has been made and which are of current
interest to various theoretical and clinical disciplines. Each
topic has been dealt with by an established expert. Clinical
subjects of relevant importance are included. Catecholamines are of
interest in pharmacology, physiology, biochemistry, as well as in
neurology, psychiatry, internal medicine (cardiology, hypertension,
asthma), ophthalmology and anesthesiology.
Monoamine oxidase (MAO) is linked to psychiatric and neurological
disorders, because inhibitors of the enzyme are used clinically for
treatment of affective disorders and Parkinson s disease. One of
the interesting new aspects of MAO is the occurrence in the human
population of deletions of genes coding for one or the other enzyme
subtype (A or B). This leads to the possibility of a genetic basis
for psychiatric disorders based on MAO. Subjects with deletions of
type A or B, and combined deletions, have been described. In the
first group of 6 papers in this book, the occurrence and
characterization of these phenotypes, as well as the structure of
MAO genes, is explored. Advances in the biochemistry of MAO
subtypes and their physiological function and localization in brain
and periphery is included. Other sections of the book deal with the
neuroprotective action of MAO inhibitors and their pharmacology,
especially the pharmacology of new MAO-B inhibitors."
Monoamine oxidase plays a major role in the pathogenesis of
neuropsychiatric disorders including depressive illness, Parkinsons
disease and Alzheimers disease. The new generation of selective
monoamine oxidase inhibitors, devoid of major side effects, has
found a prominent place in the treatment of these diseases. Some of
these drugs may have neuroprotective activity with prospects for
treating progressive neurodegenerative diseases. The volume
presents a collection of research papers on monoamine oxidase and
its inhibitors. The topic is treated from the point of view of
chemistry, biochemistry, pharmacology, physiology, neurology and
psychiatry. The book serves as a quick and comprehensive reference
source for obtaining the most up to date information."
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