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For more than a century, bioactive heterocycles have formed one of
the largest areas of research in organic chemistry. They are
important from a biological and industrial point of view as well as
to the understanding of life processes and efforts to improve the
quality of life. Heterogeneous Catalysis: A Versatile Tool for the
Synthesis of Bioactive Heterocycles highlights the recent
methodologies used in the synthesis of such bioactive systems and
focuses on the role of heterogeneous catalysis in the design and
synthesis of various biologically active heterocyclic compounds of
pharmacological interest. Topics include: Synthetic protocols for
the construction of heterocyclic systems employing silica-bound
catalysts Recent advances in heterogeneous copper-catalyzed
reactions for the synthesis of bioactive heterocycles Features of
silica-based heterogeneous catalysts, such as abundance, ease of
use, and stability Ultrasound as an effective tool for accelerating
reactions Organic transformations catalyzed by nano-ZnO as a
valuable heterogeneous catalyst Heterogeneous catalysts employed in
the synthesis of coumarins Heterocyclizations in the presence of
silver salts Home-made organometallic silica sources, known as
silatranes Reflecting the focused studies currently conducted in
these areas, the book also examines anticancer, antifungal,
antibacterial, anti-HIV, anti-inflammatory, antioxidant, and many
more biological activities of heterocyclic compounds. It is
essential reading for postgraduate and research scholars in the
fields of biochemistry, chemical biology, medicinal chemistry and
pharmaceutical chemistry.
This timely book provides a succinct summary of methods for the
synthesis of bioactive heterocycles using a multicomponent reaction
(MCR) approach. The majority of pharmaceuticals and biologically
active agrochemicals are heterocycles while countless additives and
modifiers used in industrial applications are heterocyclic in
nature. With the recent introduction of high-throughput biological
evaluation, the importance of MCRs for drug discovery has been
recognized and considerable efforts have been focused especially on
the design and development of multi-component procedures for the
generation of various bioactive heterocycles due to their
significant therapeutic potential.
This timely book provides a succinct summary of methods for the
synthesis of bioactive heterocycles using a multicomponent reaction
(MCR) approach. The majority of pharmaceuticals and biologically
active agrochemicals are heterocycles while countless additives and
modifiers used in industrial applications are heterocyclic in
nature. With the recent introduction of high-throughput biological
evaluation, the importance of MCRs for drug discovery has been
recognized and considerable efforts have been focused especially on
the design and development of multi-component procedures for the
generation of various bioactive heterocycles due to their
significant therapeutic potential.
For more than a century, bioactive heterocycles have formed one of
the largest areas of research in organic chemistry. They are
important from a biological and industrial point of view as well as
to the understanding of life processes and efforts to improve the
quality of life. Heterogeneous Catalysis: A Versatile Tool for the
Synthesis of Bioactive Heterocycles highlights the recent
methodologies used in the synthesis of such bioactive systems and
focuses on the role of heterogeneous catalysis in the design and
synthesis of various biologically active heterocyclic compounds of
pharmacological interest. Topics include: Synthetic protocols for
the construction of heterocyclic systems employing silica-bound
catalysts Recent advances in heterogeneous copper-catalyzed
reactions for the synthesis of bioactive heterocycles Features of
silica-based heterogeneous catalysts, such as abundance, ease of
use, and stability Ultrasound as an effective tool for accelerating
reactions Organic transformations catalyzed by nano-ZnO as a
valuable heterogeneous catalyst Heterogeneous catalysts employed in
the synthesis of coumarins Heterocyclizations in the presence of
silver salts Home-made organometallic silica sources, known as
silatranes Reflecting the focused studies currently conducted in
these areas, the book also examines anticancer, antifungal,
antibacterial, anti-HIV, anti-inflammatory, antioxidant, and many
more biological activities of heterocyclic compounds. It is
essential reading for postgraduate and research scholars in the
fields of biochemistry, chemical biology, medicinal chemistry and
pharmaceutical chemistry.
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