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The study of cell membranes began to attract increasing interest
before the turn of the present century with the observations of 0
verton. Since that time many investigators have become interested
in the broad problem of structure and function of the membrane and
today we find ourselVes at a stage in which several branches of
research, particularly physical chemistry, biochemistry,
biophysics, physiology and pharmacology have come together, leading
to the possibility of obtaining a better perspective of the overall
problems. The purpose of this Symposium was to assemble in an
orderly sequence representations of the knowledge of membranes
achieved to date in the areas of the various disciplines. It was
thought that to bring together many points of view on a problem
should allow the conferees to see better what had been
accomplished, what has been overlooked and what needs further
development. It is to be hoped that efforts of this type have and
will fulfill the desired purpose. This volume contains the majority
of the papers contributed by the participants in the Symposium. In
addition, it seemed logical to place at the beginning of each
chapter at least one general survey of the subject which would help
those who were less acquainted with the problem to derive the most
benefit from their reading.
The decision, in 1975, to write alone a monograph on micro tubules
was not without risks. While I was familiar from its start in
Brussels in 1934 with the work on col chicine and other mitotic
poisons, the literature on microtubules was, 8 years ago, already
increasing at an impressive rate. However, this monograph, which,
contrary to other works on microtubules, tried to cover the whole
field of research, from the fundamentals of the tubulin molecule
and the possible role of these organelles in some aspects of human
pathology, to some medical applications of microtubule poisons, has
been accepted as a useful tool for workers in these fields. Since
1976, (date of the last references mentioned in the monograph)
until the middle of 1983, papers on microtubule research have
literally been pouring in, at the rate of several hundred a year.
This may justify a second edition, although the considerable
difficulties in keeping the size of the book within the same limits
while not forgetting to mention some important work, could not be
overlooked. The need for an entirely revised and rewritten edition
prompted this new venture and was possible with the help of the
considerable amount of reprints kindly sent to me day after day
over the years. This work would have been unthinkable if the author
had not maintained the same enthusiasm for microtubule research,
which has been disclosing new facts every day."
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